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Identification of organelles and cellular factors involved in the assembly and budding of Araraquara hantavirus (ARAQV)

Grant number: 15/26667-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2016
Effective date (End): February 28, 2018
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Luis Lamberti Pinto da Silva
Grantee:Julianne Vargas de Carvalho
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/02438-6 - Studies with Bunyaviridae that produce human disease, AP.TEM

Abstract

Among the hantaviruses identified in Brazil that cause Hantavirus Pulmonary and Cardiovascular Syndrome are the Araraquara (ARQV), Juquitiba/Araucaria, Laguna Negra-like, Castelo dos Sonhos and Anajatuba viruses. Hantaviruses are rodent, and other small mammal, viruses that are transmitted to humans by inhalation of viral particles in aerosols from the contaminated urine, droppings or saliva of these animals. Since the first case of the disease reported in Brazil, in 1993, approximately 1650 other cases were reported until 2013, with a lethality of 39%. Despite their great importance in public health very little is known about the replication cycle of Hantaviruses. Thus, in the present project we propose to study the molecular and cellular mechanisms involved in the assembly and budding of ARAQV in human cells. Specifically, we will determine the cell compartments that serve as assembly sites of this virus and the possible participation of ESCRT, Rab and Arf1 molecules in these processes. The better understanding of these crucial events in viral replication cycle will provide important insights into the biology of ARAQV and could contribute to the design of strategies to inhibit viral replication. (AU)