Study of the mechanic properties of tridimensional models of polymeric stents

• Grant number: 15/14460-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2016
• End date: January 31, 2017
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Aron Jose Pazin de Andrade
• Grantee: Tamara Datysgeld Gusman Heredia
• Host Institution: Instituto Dante Pazzanese de Cardiologia (IDPC). Fundação Adib Jatene (FAJ). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Cardiovascular diseases are among the main causes of mortality in modern society, reaching approximately 30% of registered deaths worldwide. There have been various research segments striving to minimize this reality. One of invasive medical procedures, commonly performed in clinical practice, is the placement of coronary Stents. Coronary Stents have a long history, spanning a variety of materials, such as: metals, metal recovered by polymers releasing pharmacological drugs and completely bioabsorbable polymers releasing drugs. In spite of the various types of clinically used stents, some in-hospital outcomes still arise with adverse biological responses, which remain yet to be solved. Restenosis is one of the most common adverse reactions; it consists of the narrowing of the artery due to abnormal growth of smooth muscle cells, which can induce clot formation within the stent lumen. In this context, this project proposes the study of structures of polymeric stents. It is of great importance to study the development of these devices properly, since they must possess and maintain certain characteristics such as flexibility, so that they do not cause vessel trauma where they are inserted, and also maintain expandability and radial rigidity after their expansion so that the device doesn't lock itself. The creation of three-dimensional drawings of stents and its 3d printing will enable the study of forces and identification of a more adaptable structure to the vascularization in order to maintain their mechanical properties. The development of computational 3D polymeric stent models will enable a detailed view of its structures.