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Embryonic stem cells cultivation and differentiation in embryoid bodies

Grant number: 16/03553-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2016
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Henrique Marques Barbosa de Souza
Grantee:Grazielle Celeste Maktura
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:12/09602-0 - Characterization of the gene regulatory network controled by Coup-TFII in cardiomyocytes derived from embryonic stem cells, AP.JP


One of the mysteries in studying the differentiation of CTE as a model for embryonic development is the phenomenon of generating, in vitro, cells and embryonic tissues without signaling located of extraembryonic tissues, essential for the development of the embryo, and morphogenetic movements of gastrulation that culminate in origin and spatial distribution of the three germ layers; ectoderm, mesoderm and endoderm. This phenomenon has been extensively studied through the spontaneous differentiation of CTE into embryoid bodies, cell aggregates in ball form, when grown in suspension, maintain a dimensional relationship, where different programs of cellular differentiation in embryoid bodies are activated in random regions. Recent results obtained in the first year of implementation of this project revealed that the Coup-TFII gene is expressed in embryoid bodies in a hemispheric pattern, meeting with the notion of random spatial patterning observed in embryoid bodies differentiated. (AU)

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