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Synaptonemal complex organization and meiotic behavior of B chromosomes in Astatotilapia latifasciata

Grant number: 16/03912-9
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 02, 2016
Effective date (End): November 01, 2016
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Principal Investigator:César Martins
Grantee:Natália Bortholazzi Venturelli
Supervisor abroad: Ricardo Benavente
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Local de pesquisa : Universität Würzburg, Germany  
Associated to the scholarship:13/25234-4 - Meiotic behavior of B chromosomes in the cichlid fish Astatotilapia latifasciata, based on synaptonemal complex and immunocytogenetic analyses, BP.DR


The eukaryote genome is composed of classical DNA sequences and selfish elements, which do not obey the laws of Mendelian inheritance. Among these sequences are transposons, cytoplasmic factors and B chromosomes. Along the advances in chromosomal studies, B chromosomes are no longer seen as parasitic elements, and recent data have shown these chromosomes may have important biological role. B chromosomes studies have been conducted mostly in cytogenetic level, and latest molecular biology approaches may help understanding B chromosome biology. Meiotic behavior analysis associated with the application of new technologies, such as immunostaining and super resolution microscopy, may contribute to better understand the relevance of this genomic element. This project aims to advance understanding the molecular architecture of the synaptonemal complex (SC) using antibodies against SC protein and super resolution microscopy to clarify the meiotic behavior of B chromosomes. (AU)