DEVELOPMENT AND EVALUATION OF A FLAVONOID ENRICHED EMULSION WITH SUN PROTECTION FACTOR

• Grant number: 15/25533-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2016
• End date: July 31, 2018
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Leticia Caramori Cefali
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 17/14757-7 - Development and evaluation of sun protection factor of emulsion containing extract rich in flavonoids, BE.EP.DR

Abstract

Sunscreens are necessary to prevent skin diseases, specially skin cancer, and they prevent against premature skin aging. The aim of this study is evaluation of sun protection factor of extract containing flavonoids to be incorporated into topical formulation. It will be used vegetal material containing flavonoids to obtain a rich extract. After evaluating the flavonoids concentration in extract and its proof of absorption in ultraviolet region in spectrophotometer, its citotoxity and antioxidant activities will be evaluated and these will contributed to combat premature skin aging. Extract will be incorporate in formula for topical use and it will be development and its physic-chemical stability will be evaluated. Formula will also be submitted to cutaneous permeation test for the assessment of its ability to remain in stratum corneum, epidermis and dermis for effective skin protection against sun rays. Therefore, formula containing rich extract of flavonoids will be can used in sunscreens and thus it will be an alternative to combat the deleterious effects from exposure to ultraviolet radiation.

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CEFALI, LETICIA CARAMORI; VAZQUEZ, CAROLINA; ATAIDE, JANAINA ARTEM; FIGUEIREDO, MARIANA CECCHETTO; RUIZ, ANA LUCIA TASCA GOIS; FOGLIO, MARY ANN; LANCELLOTTI, MARCELO; MAZZOLA, PRISCILA GAVA. In vitro activity and formulation of a flavonoid-containing cashew pulp extract for the topical treatment of acne and the protection of skin against premature aging. NATURAL PRODUCT RESEARCH, APR 2020. (15/25533-7)

CEFALI, LETICIA CARAMORI; ATAIDE, JANAINA ARTEM; FERNANDES, ANA RITA; DE OLIVEIRA SOUSA, ILZA MARIA; DA SILVA GONCALVES, FERNANDA CRISTINA; EBERLIN, SAMARA; DAVILA, JOSE LUIS; JOZALA, ANGELA FAUSTINO; CHAUD, MARCO VINICIUS; SANCHEZ-LOPEZ, ELENA; et al. Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties. ANTIOXIDANTS, v. 8, n. 10, OCT 2019. (15/25533-7, 17/14757-7)

CEFALI, LETICIA CARAMORI; ATAIDE, JANAINA ARTEM; FERNANDES, ANA RITA; SANCHEZ-LOPEZ, ELENA; DE OLIVEIRA SOUSA, ILZA MARIA; FIGUEIREDO, MARIANA CECCHETTO; TASCA GOIS RUIZ, ANA LUCIA; FOGLIO, MARY ANN; MAZZOLA, PRISCILA GAVA; SOUTO, ELIANA BARBOSA. Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinifera L.. PLANTS-BASEL, v. 8, n. 11, NOV 2019. (17/14757-7, 15/25533-7)

CEFALI, LETICIA CARAMORI; VAZQUEZ, CAROLINA; ATAIDE, JANAINA ARTEM; FIGUEIREDO, MARIANA CECCHETTO; RUIZ, ANA LUCIA TASCA GOIS; FOGLIO, MARY ANN; LANCELLOTTI, MARCELO; MAZZOLA, PRISCILA GAVA. In vitro activity and formulation of a flavonoid-containing cashew pulp extract for the topical treatment of acne and the protection of skin against premature aging. NATURAL PRODUCT RESEARCH, v. 35, n. 23, p. 7-pg., 2020-04-20. (15/25533-7)

CEFALI, LETICIA CARAMORI; FRANCO, JULIA GOMES; NICOLINI, GIULIA FERREIRA; ATAIDE, JANAINA ARTEM; MAZZOLA, PRISCILA GAVA. In vitro antioxidant activity and solar protection factor of blackberry and raspberry extracts in topical formulation. Journal of Cosmetic Dermatology, v. 18, n. 2, p. 539-544, APR 2019. (15/25533-7)

CEFALI, LETICIA CARAMORI; FRANCO, JULIA GOMES; NICOLINI, GIULIA FERREIRA; DOS SANTOS, ERICA MENDES; MASQUETTI FAVA, ANA LAURA; FIGUEIREDO, MARIANA CECCHETTO; ATAIDE, JANAINA ARTEM; FOGLIO, MARY ANN; MAZZOLA, PRISCILA GAVA. Jaboticaba, a Brazilian jewel, source of antioxidant and wound healing promoter. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 20, MAY 2021. (15/25533-7)

FRANCO, JULIA GOMES; CEFALI, LETICIA CARAMORI; ATAIDE, JANAINA ARTEM; SANTINI, ANTONELLO; SOUTO, ELIANA B.; MAZZOLA, PRISCILA GAVA. Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): A green source of flavonoids with antioxidant and photoprotective properties. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 23, OCT 2021. (15/25533-7, 17/14757-7, 17/05275-9)

CEFALI, LETICIA CARAMORI; ATAIDE, JANAINA ARTEM; EBERLIN, SAMARA; DA SILVA GONCALVES, FERNANDA CRISTINA; FERNANDES, ANA RITA; MARTO, JOANA; RIBEIRO, HELENA MARGARIDA; FOGLIO, MARY ANN; MAZZOLA, PRISCILA GAVA; SOUTO, ELIANA BARBOSA. In vitro SPF and Photostability Assays of Emulsion Containing Nanoparticles with Vegetable Extracts Rich in Flavonoids. AAPS PHARMSCITECH, v. 20, n. 1, JAN 2019. (15/25533-7, 17/14757-7)

CEFALI, LETICIA CARAMORI; ATAIDE, JANAINA ARTEM; DE OLIVERIA SOUSA, ILZA MARIA; FIGUEIREDO, MARIANA CECCHETTO; TASCA GOIS RUIZ, ANA LUCIA; FOGLIO, MARY ANN; MAZZOLA, PRISCILA GAVA. In vitrosolar protection factor, antioxidant activity, and stability of a topical formulation containing Benitaka grape (Vitis viniferaL.) peel extract. NATURAL PRODUCT RESEARCH, v. 34, n. 18, p. 2677-2682, SEP 16 2020. (15/25533-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CEFALI, Leticia Caramori. Study of sun protection factor of extracts rich in flavonoids into topical formulation. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.