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Comparison of methods for admixture and heterosis mapping in crossbred cattle populations

Grant number: 16/07531-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): July 11, 2016
Effective date (End): February 25, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:José Fernando Garcia
Grantee:Yuri Tani Utsunomiya
Supervisor abroad: Johann Solkner
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Local de pesquisa : Universität für Bodenkultur Wien, Austria  
Associated to the scholarship:14/01095-8 - Use of next generation sequencing for the fine mapping of loci explaining variance in scrotal circumference in Nellore cattle, BP.DR

Abstract

Crossbreeding is a promising strategy to overcome the global challenge of supplying food to over 9 billion people by 2050. Crossbred animals usually combine favorable traits from their purebred ancestors, and in many cases their performance exceeds the parent average. This phenomenon, known as heterosis or 'hybrid vigor', is a genetic dominance effect, best expressed when the parental alleles differ drastically in frequency. Therefore, a major challenge in breeding programs exploring crossbreeding is to predict dominance deviations from average effects encoded by conventional breeding values. Currently, little development has been observed in cattle genomics regarding strategies for admixture and heterosis mapping, and this is a priority in South America, Europe and West Africa, where different types of crossbreeding strategies are emerging to increase productivity together with fitness. Of special interest, beef and milk production must be sustainable and coupled with satisfactory heat tolerance, fertility and disease resilience. Using real and simulated genomic and phenotypic data, the present proposal aims at evaluating methods for admixture and heterosis mapping. Scenarios matching crossbreeding carried out in Europe for Swiss Fleckvieh cattle, in South America for Girolando cattle and in West Africa for trypanotolerant crosses will be evaluated.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AGUIAR, TAMIRIS SAYURI; PINTOR TORRECILHA, RAFAELA BEATRIZ; MILANESI, MARCO; HARTH UTSUNOMIYA, ADAM TAITI; TRIGO, BEATRIZ BATISTA; TIJJANI, ABDULFATAI; MUSA, HASSAN HUSSEIN; LOPES, FLAVIA LOMBARDI; AJMONE-MARSAN, PAOLO; CARVALHEIRO, ROBERTO; DE REZENDE NEVES, HAROLDO HENRIQUE; DO CARMO, ADRIANA SANTANA; HANOTTE, OLIVIER; SONSTEGARD, TAD STEWART; GARCIA, JOSE FERNANDO; UTSUNOMIYA, YURI TANI. Association of Copy Number Variation at Intron 3 of HMGA2 With Navel Length in Bos indicus. FRONTIERS IN GENETICS, v. 9, DEC 7 2018. Web of Science Citations: 1.
KHAYATZADEH, N.; MESZAROS, G.; UTSUNOMIYA, Y. T.; SCHMITZ-HSU, F.; SEEFRIED, F.; SCHNYDER, U.; FERENCAKOVIC, M.; GARCIA, J. F.; CURIK, I.; SOELKNER, J. Effects of breed proportion and components of heterosis for semen traits in a composite cattle breed. JOURNAL OF ANIMAL BREEDING AND GENETICS, v. 135, n. 1, p. 45-53, FEB 2018. Web of Science Citations: 0.
UTSUNOMIYA, YURI TANI; MILANESI, MARCO; HARTH UTSUNOMIYA, ADAM TAITI; PINTOR TORRECILHA, RAFAELA BEATRIZ; KIM, EUI-SOO; COSTA, MARCIO SILVA; AGUIAR, TAMIRIS SAYURI; SCHROEDER, STEVEN; DO CARMO, ADRIANA SANTANA; CARVALHEIRO, ROBERTO; REZENDE NEVES, HAROLDO HENRIQUE; MOROZINI PADULA, ROMULO CLAUDIO; SUSSAI, THAYLA SOUZA; ZAVAREZ, LUDMILLA BALBO; CIPRIANO, RAFAEL SILVA; THEODORO CAMINHAS, MARIA MARGARETH; HAMBRECHT, GEORGE; COLLI, LICIA; EUFEMI, ELISA; AJMONE-MARSAN, PAOLO; CESANA, DENEB; SANNAZARO, MARCO; BUORA, MAURIZIO; MORGANTE, MICHELE; LIU, GEORGE; BICKHART, DEREK; VAN TASSELL, CURTIS PAUL; SOLKNER, JOHANN; SONSTEGARD, TAD STEWART; GARCIA, JOSE FERNANDO. A PLAG1 mutation contributed to stature recovery in modern cattle. SCIENTIFIC REPORTS, v. 7, DEC 7 2017. Web of Science Citations: 9.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.