Vanadium haloperoxidase: searching for new sources and their application in continuous flow system aiming selective reactions

• Grant number: 16/05633-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2016
• End date: December 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Claudimir Lucio Do Lago
• Grantee: Juliana Caldeira Abreu
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Nature has developed an extensive repertoire of strategies to incorporate halogens into organic molecules. The haloperoxidase is a group capable of introducing halogen atom into nucleophilic organic molecules. Among the haloperoxidases, the vanadium dependent displays synthetic advantages that corroborate with its application as a biocatalyst, such as tolerance to organic solvents, high temperatures, as well the capability to halogenate wide range of organic compounds, in a manner of high selectivity. Despite the above advantages, in the literature several problems of applying these enzymatic methodologies can be found. The high reactivity of the halogenating specie generated by the enzyme can be the reason for some non-selective reactions. We believe that the use of a reactor with high operational stability, coupled with the "flash chemistry" concept can promote a controlled and continuous generation of the reactive intermediate, which could contribute with the most favored kinetically reaction, resulting in a selective process. Thus, this project aims to search new sources of vanadium haloperoxidases, followed by their immobilization. We also intend to study the role of continuous flow system in the selectivity. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREIA, VALQUIRIO G.; ABREU, JULIANA C.; BARATA, CAIO A. E.; ANDRADE, LEANDRO H.. Iron-Catalyzed Synthesis of Oxindoles: Application to the Preparation of Pyrroloindolines. ORGANIC LETTERS, v. 19, n. 5, p. 1060-1063, MAR 3 2017. (16/05633-0, 13/04540-0, 14/22457-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ABREU, Juliana Caldeira. Stability-indicating method development for Bromopride and its degradation products applying Analytical Quality by Design principles. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.