Synthesis of glibenclamide new derivatives in order to obtain potential antihyperglycemic drugs

• Grant number: 16/08569-0
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): July 01, 2016
• Effective date (End): December 03, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ronaldo Aloise Pilli
• Grantee: Francisco Fávaro de Assis
• Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
• Associated scholarship(s): 17/06836-4 - Synthesis of Dihydrocoumarins-C-Aryl glucosides as potential SGLT2 inhibitors using asymmetric photoredox catalysis, BE.EP.PD

Abstract

The research proposal aims to prepare a small library of analogues of Glibenclamide in order to be in vivo evaluated as anti-hyperglicemic agents. Analogues containing the piperazine moiety as a spacer between the amide and phenylsulfonil groups of Glibenclamide will be prepared. The use of flow chemistry methodology will be considered for scaling up the synthesis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PILLI, RONALDO A.; DE ASSIS, FRANCISCO F. Organic Synthesis: New Vistas in the Brazilian Landscape. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 895-941, 2018. Web of Science Citations: 0.

RONALDO A. PILLI; FRANCISCO F. DE ASSIS. Organic Synthesis: New Vistas in the Brazilian Landscape. Anais da Academia Brasileira de Ciências, v. 90, n. 1, p. -, 2018.