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Characterization of the effects of supplementation of beta-hydroxybutyrate salts in plasma parameters, adipose tissue morphology and expression of adiponectin

Grant number: 16/10218-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2016
Effective date (End): December 31, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Fabio Bessa Lima
Grantee:Ayumi Cristina Medeiros Komino
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


In recent years, studies have been published on the possible beneficial effects of physiological ketosis. Several diseases such as Epilepsy, Alzheimer's disease, Parkinson's disease and Metabolic Syndrome, have been shown treatable with ketogenic diets. However, little is known about the effects of ketone bodies alone on metabolic parameters influenced by ketogenic diets. Our project has the intention to test a model of supplementation with ²-hydroxybutyrate salts in rats and analyze some metabolic parameters benefit from ketogenic diets that, in our assumptions may be altered by supplementation of ketone bodies. Repercussions in food intake, body mass and fat body will be investigated, as well as ketonemia, blood glucose, blood cholesterol, triglycerides and adiponectinemia. Still, a more detailed analysis will be performed with samples of visceral and subcutaneous adipose tissue, where fat cells are isolated and morphometric parameters analyzed. Finally, the gene expression of adiponectin in adipose tissue will be quantified by real-time RT-PCR. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMINHOTTO, RENNAN DE OLIVEIRA; MEDEIROS KOMINO, AYUMI CRISTINA; SILVA, FLAVIANE DE FATIMA; ANDREOTTI, SANDRA; LAURATO SERTIE, ROGERIO ANTONIO; REIS, GABRIELA BOLTES; LIMA, FABIO BESSA. Oral beta-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats. NUTRITION & METABOLISM, v. 14, APR 24 2017. Web of Science Citations: 6.

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