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Determination of Aedes aegypti natural populations susceptibility to dengue virus

Grant number: 16/14798-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2017
Field of knowledge:Biological Sciences - Parasitology - Entomology and Malacology of Parasites and Vectors
Cooperation agreement: Keele University
Principal researcher:Jayme Augusto de Souza-Neto
Grantee:Pedro Henrique de Andrade Affonso
Home Institution: Instituto de Biotecnologia (IBTEC). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:13/11343-6 - Characterization of the microbiota-mediated anti-dengue mechanisms in wild Aedes aegypti populations, AP.JP


The elucidation of genetic factors related to A. aegypti vector competence has been facilitated by the dissection of the mosquito's transcriptional responses to DENV, as well as by QTL studies in populations with midgut infection and scape barriers (MIM and MEB). Similar studies in Brazilian A. aegypti populations are limited to the fact that mosquito populations with different levels of susceptibility to DENV have already not been properly identified and colonized. The obtention of such populations will facilitate not only studies characterizing the genetic factors associated to mosquito's vector competence, but alto the understanding of the influence of the gut microbiota in this process. (AU)