The therapeutic efficacy of drugs widely used in cancer treatments for a range of different types of cancerous tumor and other pathologies are found to be affected by intrinsic or acquired resistance that may develop during the treatment, and this has in essence become one of the most crucial problems of medicine, more specifically in therapy against cancer. It is in this light that the development of analytical methods aiming at monitoring the chemotherapy resistance and consequently the monitoring of the effectiveness of anticancer drugs stand to be of imperative relevance and of great interest once they play a major role in improving clinical treatments. This can be attained through the study of the action mechanism and the properties of detoxification enzymes that can be used in devices for the detection of problems related to drug metabolism. Therefore, the overall objective of the project lies in studying the action mechanism of detoxification enzymes such as metalotionenina, cytochrome P450, and glutathione-S-transferase present in the metabolism of neoplastic drugs, and this knowledge once acquired will be implemented in the simultaneous detection of platinum compounds (cisplatin), methotrexate, tamoxifen, doxorubicin and gemcitabine in modified screen-printed multichannel electrodes and field-effect transistors and thus contributing towards the improvement of chemotherapy treatments.
News published in Agência FAPESP Newsletter about the scholarship: