Comparison of minimally invasive autopsy and conventional autopsy for post-mortem malignant neoplasm diagnosis

• Grant number: 16/03461-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2016
• End date: October 31, 2019
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Paulo Hilário Nascimento Saldiva
• Grantee: Lisie Tocci Justo Luvizutto
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU), AP.TEM

Abstract

Since ancient times, passing through the first known anatomic studies in the Middle Ages to the use of modern molecular techniques for the study of physiopathological processes, autopsy has shown to be a very rich source of material and inspiration for the advancement of scientific knowledge. Although a wide range of imaging techniques have emerged, several studies have shown that the autopsy remains crucial for: the complete assessment of the disease process, the assessment of new pathologies and quality control of the medical service. Autopsy also allows for the development of concomitant and associated projects in different areas due to the abundance of material. The School of Medicine of the University of Sao Paulo (FMUSP) seeks to make the best possible use of the great potential of its 14,000 annually autopsies Death Verification Service of Sao Paulo. Although it seems logical that the increased capacity of imaging techniques to observe biological alterations results in more reliable correlation, validations are, in general, conceptually performed on a daily basis of equipment use, based on assumptions, rather than in structured clinical/histological/imaging correlation studies. However, in spite of their several scientific contributions, the volume of studies post-mortem is small, as it is difficult to obtain specimens on a routine basis. The objective of the present proposal is to use this new imaging facility to explore the concept of minimally invasive autopsy as an alternative to increase the number of autopsies and reinforce its importance not only as a diagnostic tool , but also as a way to promote the generation of new knowledge of tumor biology.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CREMASCO TAKANO, ANA PAULA; JUSTO, LISIE TOCCI; DOS SANTOS, NATHALIA VILLA; MARQUEZINI, MONICA VALERIA; DE ANDRE, PAULO AFONSO; MONTEIRO DA ROCHA, FRANCISCO MARCELO; PASQUALUCCI, CARLOS AUGUSTO; BARROZO, LIGIA VIZEU; SINGER, JULIO M.; SALDIVA DE ANDRE, CARMEN DIVA; et al. Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. Environmental Research, v. 173, p. 23-32, JUN 2019. (16/22793-0, 16/23129-7, 16/03461-7, 13/21728-2)

DOS SANTOS, NATHALIA VILLA; VIEIRA, CAROLINA LETICIA ZILLI; SALDIVA, PAULO HILARIO NASCIMENTO; DE ANDRE, CARMEN DIVA SALDIVA; MAZZILLI, BARBARA PACI; ANDRADE, MARIA DE FATIMA; SAUEIA, CATIA HELOISA; SAIKI, MITIKO; VERAS, MARIANA MATERA; KOUTRAKIS, PETROS. Accumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollution. SCIENTIFIC REPORTS, v. 12, n. 1, p. 7-pg., 2022-06-30. (16/22793-0, 13/21728-2, 16/03461-7, 16/23129-7)

DOS SANTOS, NATHALIA VILLA; ZILLI VIEIRA, CAROLINA LETICIA; NASCIMENTO SALDIVA, PAULO HILARIO; MAZZILLI, BARBARA PACI; SAIKI, MITIKO; SAUEIA, CATIA HELOISA; SALDIVA DE ANDRE, CARMEN DIVA; JUSTO, LISIE TOCCI; NISTI, MARCELO BESSA; KOUTRAKIS, PETROS. Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil. SCIENTIFIC REPORTS, v. 10, n. 1, JAN 13 2020. (13/21728-2, 16/03461-7, 16/22793-0, 16/23129-7)