Validation and association of non tolerated SNPs with muscle growth and fat deposition traits in chickens

• Grant number: 16/13589-0
• Support type: Scholarships in Brazil - Master
• Effective date (Start): September 01, 2016
• Effective date (End): February 28, 2018
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal researcher: Luiz Lehmann Coutinho
• Grantee: Priscila Anchieta Trevisoli
• Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated research grant: 14/08704-0 - Identification of loci of interest for poultry production, AP.TEM

Abstract

The domestic chicken is an important farm animal with protein of high biological value for human consumption. Technological advances in animal genomics have contributed to the development of tools that can be used in animal breeding programs, such as the next generation sequencing that allowed polymorphisms identification and the generation of dense SNP panels for large-scale genotyping. The studies of SNPs in QTL regions with emphasis on the search for causal mutations have great importance for breeding. Identification of causal mutations allows a greater better understanding of the biological process involved in the phenotype of interest, reducing the number of SNPs on a chip and consequently increasing the reliability and reducing cost of genotyping. SNPs not tolerated are those which may alter protein function, and these are predicted by SIFT tool (Sort Intolerant From Tolerant). In this project will be selected 48 non-tolerated SNPs in QTL regions that were previously identified in Brazilian experimental chicken lines from EMBRAPA Swine and Poultry. The main objective of this study is to perform association analysis of 48 selected SNPs with growth and fat deposition traits in broilers. The information that will be generated in this project will help to identify possible causal mutations in regions of economic interest in chickens. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TREVISOLI, PRISCILA ANCHIETA; MONTEIRO MOREIRA, GABRIEL COSTA; BOSCHIERO, CLARISSA; MELLO CESAR, ALINE SILVA; PETRINI, JULIANA; ALVES MARGARIDO, GABRIEL RODRIGUES; LEDUR, MONICA CORREA; MOURAO, GERSON BARRETO; GARRICK, DORIAN; COUTINHO, LUIZ LEHMANN. A Missense Mutation in the MYBPH Gene Is Associated With Abdominal Fat Traits in Meat-Type Chickens. FRONTIERS IN GENETICS, v. 12, AUG 11 2021. Web of Science Citations: 1.