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Genome wide association studies for fat deposition and carcass yield in chickens

Grant number: 14/21380-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2015
Effective date (End): March 02, 2018
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Luiz Lehmann Coutinho
Grantee:Gabriel Costa Monteiro Moreira
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:14/08704-0 - Identification of loci of interest for poultry production, AP.TEM
Associated scholarship(s):16/00569-1 - Imputation and genome-wide association analysis using haplotypes for abdominal fat in chickens, BE.EP.DR

Abstract

The chicken meat production in Brazil has a recognized importance in world economy as a result of the continuous improvement of performance traits, mainly due to breeding programs. Selected animals for rapid growth and increased muscle deposition also exhibited increased fat deposition in carcass. The excess of fat deposition in carcass is a negative factor to the production considering the cost, the difficulty of processing and also the product depreciation. The identification of genetic components responsible for a part of phenotypic variation is fundamental in breeding programs allowing the selection of animals which have the phenotypic trait of interest. Fat deposition is a trait controlled by several genes that participate in lipid metabolism. New technologies such as high throughput genotyping that uses SNP chips have allowed the genomic association with genotype and different phenotypic trait of interest. The aim of this study is to identify regions and candidates genes associated with traits related to fat deposition and carcass yield by genome wide association (GWAS). To achieve this objective, it will be performed the genotyping of 2,000 animals with high dense SNP chip Chicken 600K Affymetrix®Axiom® (1,500 from the broiler reference population TT and 500 from F2 experimental population, both from EMBRAPA Swine and Poultry). GWAS will be performed for 22 phenotypes involved in fat deposition and carcass yield. It is expected to find genomic regions associated with these traits. The results will allow the identification of positional candidate genes related to the traits studied. (AU)

Articles published in other media outlets: (2 total)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO MOREIRA, GABRIEL COSTA; POLETI, MIRELE DAIANA; PERTILLE, FABIO; BOSCHIERO, CLARISSA; MELLO CESAR, ALINE SILVA; GODOY, THAIS FERNANDA; LEDUR, MONICA CORREA; REECY, JAMES M.; GARRICK, DORIAN J.; COUTINHO, LUIZ LEHMANN. Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach. BMC GENETICS, v. 20, n. 1 NOV 6 2019. Web of Science Citations: 0.
MONTEIRO MOREIRA, GABRIEL COSTA; SALVIAN, MAYARA; BOSCHIERO, CLARISSA; MELLO CESAR, ALINE SILVA; REECY, JAMES M.; GODOY, THAIS FERNANDA; LEDUR, MONICA CORREA; GARRICK, DORIAN; MOURAO, GERSON BARRETO; COUTINHO, LUIZ L. Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens. BMC Genomics, v. 20, n. 1 AUG 22 2019. Web of Science Citations: 0.
COSTA ALMEIDA, OCTAVIO AUGUSTO; MONTEIRO MOREIRA, GABRIEL COSTA; REZENDE, FERNANDA MARCONDES; BOSCHIERO, CLARISSA; PEIXOTO, JANE DE OLIVEIRA; GUARATINI IBELLI, ADRIANA MERCIA; LEDUR, MONICA CORREA; DE NOVAIS, FRANCISCO JOSE; COUTINHO, LUIZ LEHMANN. Identification of selection signatures involved in performance traits in a paternal broiler line. BMC Genomics, v. 20, JUN 3 2019. Web of Science Citations: 0.
MOREIRA, GABRIEL COSTA MONTEIRO; BOSCHIERO, CLARISSA; MELLO CESAR, ALINE SILVA; REECY, JAMES M.; GODOY, THAIS FERNANDA; PERTILLE, FABIO; LEDUR, MONICA CORREA; MEIRA TAVARES MOURA, ANA SILVIA ALVES; GARRICK, DORIAN J.; COUTINHO, LUIZ LEHMANN. Integration of genome wide association studies and whole genome sequencing provides novel insights into fat deposition in chicken. SCIENTIFIC REPORTS, v. 8, NOV 1 2018. Web of Science Citations: 4.
MONTEIRO MOREIRA, GABRIEL COSTA; BOSCHIERO, CLARISSA; MELLO CESAR, ALINE SILVA; REECY, JAMES M.; GODOY, THAIS FERNANDA; TREVISOLI, PRISCILA ANCHIETA; CANTAO, MAURICIO E.; LEDUR, MONICA CORREA; GUARATINI IBELLI, ADRIANA MERCIA; PEIXOTO, JANE DE OLIVEIRA; MEIRA TAVARES MOURA, ANA SILVIA ALVES; GARRICK, DORIAN; COUTINHO, LUIZ LEHMANN. A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens. BMC Genomics, v. 19, MAY 21 2018. Web of Science Citations: 6.
BOSCHIERO, CLARISSA; MONTEIRO MOREIRA, GABRIEL COSTA; GHEYAS, ALMAS ARA; GODOY, THAIS FERNANDA; GASPARIN, GUSTAVO; SAMPAIO CORREA MARIANI, PILAR DRUMMOND; PADUAN, MARCELA; MELLO CESAR, ALINE SILVA; LEDUR, MONICA CORREA; COUTINHO, LUIZ LEHMANN. Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines. BMC Genomics, v. 19, JAN 25 2018. Web of Science Citations: 8.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MOREIRA, Gabriel Costa Monteiro. Genome-wide association studies reveal genomic regions and positional candidate genes for fat deposition in chickens. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz Piracicaba.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.