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Surface characterization and bacterial colonization of Ti-Nb-Zr experimental ternary alloy for dental implants

Grant number: 16/11610-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2016
Effective date (End): September 30, 2017
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Valentim Adelino Ricardo Barão
Grantee:Karina Pintaudi Amorim
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


The growing demand for dental implants highlights the need to develop materials with improved properties that ensure the longevity of treatment. Titanium (Ti) alloys containing niobium (Nb) and zirconium (Zr) appear as promising candidates for the use in dental implants owing to their mechanical properties, as low elastic modulus and high ultimate tensile strength. On the other hand, the behavior of these alloys for bacterial proliferation and biofilm formation has not been reported. Biofilm formation and possible development of periimplantitis is directly related to the survival and successful of dental implants. Therefore, this study aims to characterize the surface and to evaluate the proliferation of Streptococcus sanguinis and Actinomyces naeslundii onto ternary experimental alloys of Ti-Nb-Zr. The alloys will be developed at the following compositions (mass %): Ti-35Nb-5Zr e Ti-35Nb-10Zr. Commercially pure titanium (Ticp) and the alloy based on aluminum (Al) and vanadium (V) (Ti-6Al-4V) will be used as controls. Discs' surfaces (10 mm diameter x 2 mm thickness) will be characterized by surface roughness, wettability and surface free energy. In the microbiological assay, biofilm of S. sanguinis and A. naeslundii will be evaluated in the different surfaces. The colony forming units will be determined by specific mediums (log CFU/cm2). The biofilm structure will be evaluated by scanning electron microscopy (SEM). Quantitative data will be statistically analyzed at a significant level of 5%. The number of samples for each assay will be determined by a pilot study.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PANTAROTO, HELOISA NAVARRO; AMORIM, KARINA PINTAUDI; CORDEIRO, JAIRO MATOZINHO; SOUZA, JOAO GABRIEL S.; RICOMINI-FILHO, ANTONIO PEDRO; RANGEL, ELIDIANE C.; RIBEIRO, ANA LUCIA R.; VAZ, LUIS GERALDO; BARAO, VALENTIM A. R.. Proteome analysis of the salivary pellicle formed on titanium alloys containing niobium and zirconium. BIOFOULING, v. 35, n. 2, . (16/11470-6, 16/11610-2, 14/26853-2)

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