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Osteopromotor effect of 3,3 , 5 triiodo - L- thyronine associate to trophic factors produced by endothelial cells

Grant number: 16/10392-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2016
Effective date (End): September 30, 2018
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Willian Fernando Zambuzzi
Grantee:Amanda Fantini de Camargo Andrade
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:14/22689-3 - Microvesicle/proteins-mediated paracrine signaling among bone and endothelial cells during bone development and regeneration, AP.JP


We know that osteogenesis is essential for bone renewal, as well as fracture healing through regenerative mechanisms; In addition, these processes often decrease with the progress of age, leading to bone loss and an increased incidence of fractures. Currently, bone defects constitute a public health problem when the life expectancy of the population has increased significantly. Reconstructing the lost tissue is one of the great challenges of surgeons in the area, often requiring the application of a biomaterial that allows functional repair of lost tissue. Despite its medical, social, and economic importance, little progress has been made regarding the bioassay methodologies able to rank new therapies. We now know that the development and bone regeneration is a complex event and orchestrated by paracrine mechanisms of intercellular signaling showing that osteogenesis is coupled to angiogenesis mainly from elegant work from Prof. R. H. Adams, Max Planck Institute for Molecular Biomedicine, recently published in Nature. These works justify our interest in studying the crosstalk between the osteogenic and endothelial lineages, emphasizing the importance of knowing the repertoire of molecules secreted either by osteoblasts or endothelial cells. Furthermore, it is currently known that the hormone "3,3 ', 5-triiodo-L-thyronine" plays an important role in endocrine bone remodeling. In this context, the design of the project will attack the synergistic effect of trophic factors produced by endothelial cells in osteoblast differentiation induced by thyroid hormone, triiodothyronine. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, RODRIGO A.; DE CAMARGO ANDRADE, AMANDA FANTINI; FELTRAN, GEORGIA DA SILVA; FERNANDES, CELLO JUNIOR DA C.; DE ASSIS, RAHYZA INACIO F.; FERREIRA, MARCEL RODRIGUES; ANDIA, DENISE C.; ZAMBUZZI, WILLIAN F.. The role of triiodothyronine hormone and mechanically-stressed endothelial cell paracrine signalling synergism in gene reprogramming during hBMSC-stimulated osteogenic phenotype in vitro. Molecular and Cellular Endocrinology, v. 478, p. 151-167, . (16/10392-1, 16/01139-0, 14/22689-3)

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