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Microvesicle/proteins-mediated paracrine signaling among bone and endothelial cells during bone development and regeneration

Grant number: 19/21807-6
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2020
Effective date (End): March 31, 2021
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Willian Fernando Zambuzzi
Grantee:Célio Junior da Costa Fernandes
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:14/22689-3 - Microvesicle/proteins-mediated paracrine signaling among bone and endothelial cells during bone development and regeneration, AP.JP


The skeletal system of mammals coordinate the role of a set of cells responding hierarchically to bone remodeling. In this context, we know that osteogenesis is indispensable for bone growth, as well as fracture healing through regenerative mechanisms; we know that these processes often decrease with age, leading to bone loss and an increased incidence of fractures. Currently, bone defects constitute a public health issue, since the life expectancy of the population has significantly increased. Lately, we know that bone development and regeneration is a complex event orchestrated by paracrine intercellular signaling mechanisms showing that osteogenesis and angiogenesisis are coupled. These studies justify our interest in investigating the real crosstalk between osteogenic and endothelial cells, emphasizing the importance of understanding the repertoire of molecules required in this process. At the beginning in this purpose under BCO fellowship (2016/08888-9), we clearly showed that smooth muscle cells play an important role in the acquisition of osteocytes from human osteoblasts, in addition to identifying microvesicles as an important vehicle for transporting trophic factors in this process. Now, in these additional 9 months of schedule addition, we will try to assess whether this process improves or is not modulated in response to Shear-Stress mechanosignaling, these experiments are already underway and the time required is sufficient to complete the project. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA FERNANDES, JR., CELIO; RODRIGUEZ, VICTOR MANUEL OCHOA; SOARES-COSTA, ANDREA; CIRELLI, JONI AUGUSTO; JUSTINO, DANIELA MORILHA NEO; ROMA, BARBARA; ZAMBUZZI, WILLIAN FERNANDO; FARIA, GISELE. Cystatin-like protein of sweet orange (CsinCPI-2) modulates pre-osteoblast differentiation via beta-Catenin involvement. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 32, n. 4, . (14/22689-3, 18/24150-5, 12/24278-5, 17/05784-0, 19/21807-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FERNANDES, Célio Junior da Costa. Sinalização parácrina mediada por proteínas e microvesículas entre células ósseas e seu microambiente. 2021. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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