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Complete characterization on exosome loading from endothelial cells under shear stress: a special attention to kinases and mRNA

Grant number: 18/10856-3
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): September 15, 2018
Effective date (End): July 31, 2019
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Willian Fernando Zambuzzi
Grantee:Célio Junior da Costa Fernandes
Supervisor: Maikel P. Peppelenbosch
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: Erasmus University Rotterdam (EUR), Netherlands  
Associated to the scholarship:16/08888-9 - Microvesicle/proteins-mediated paracrine signaling among bone and endothelial cells during bone development and regeneration, BP.DD


We know that the bone development and regeneration is a complex event and orchestrated by paracrine mechanisms of intercellular signaling coupling angiogenesis and osteogenesis. These evidences were showed by the elegant work published by Prof. R. H. Adams of the Max Planck Institute for Molecular Biomedicine, recently published in Nature. In this context, this project aims to characterize exosomes released by primary endothelial cells, already acquired along the LONZA; it is very important to mention that prof. Maikel Peppelenbosh will guide us in the investigation of molecules carried by these exosomes, such as kinases and transcriptome by sequencing RNA. To note, this application is linked with a current financing project from FAPESP (JP: 2014/22689-3), where our objective is to map the repertoire of molecules secreted by osteoblasts and endothelial cells and identify their effects each other during bone remodeling. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDES, CELIO JR DA COSTA; ZAMBUZZI, WILLIAN FERNANDO. Fibroblast-secreted trophic factors contribute with ECM remodeling stimulus and upmodulate osteocyte gene markers in osteoblasts. Biochimie, v. 168, p. 92-99, . (18/10856-3, 16/08888-9, 14/22689-3)

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