Evaluation of effect of surfactants on the photodynamic inactivation of Staphylococcus aureus biofilms using bacteriochlorin

• Grant number: 16/16086-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2016
• End date: October 31, 2017
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Clovis Wesley Oliveira de Souza
• Grantee: Diego Damasco Barboza
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 13/07276-1 - CEPOF - Optics and Photonic Research Center, AP.CEPID

Abstract

The resistance that some microorganisms to current treatments available being an obstacle, especially for the medical field. Moreover, the microorganisms are able to organize a highly complex structure, and even stronger than in planktonic form called biofilm. Photodynamic Inactivation (PDI) has been an alternative method of treatment, which consists of incidence of light on a sample treated with a photosensitizer. Surfactants are compounds capable of increasing permeability through the membrane, thereby increasing the permeability of the cell wall photosensitizer. This project aims to study the effect of different surfactants in photodynamic inactivation of biofilm of Staphylococcus aureus.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOZA, DIEGO D.; MARTINS, LAURA C. A.; CORREA, THAILA QUATRINI; GERALDE, MARIANA CARREIRA; PRATAVIEIRA, SEBASTIAO; DE OLIVEIRA, KLEBER THIAGO; ULIANA, MARCIANA P.; DE SOUZA, CLOVIS W.; KESSEL, DH; HASAN, T. Photodynamic inactivation of Staphylococcus aureus and Escherichia coli using a new bacteriochlorin as photosensitizer. OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XXVII, v. 10476, p. 9-pg., 2018-01-01. (09/54035-4, 13/07276-1, 16/16086-0, 14/50857-8)