Assessment of sorafenib efficacy in experimental liver carcinogenesis secondary to non-alcoholic fatty liver disease (NAFLD) by 18FDG Positron Emission computed tomography (PET-CT)

• Grant number: 16/02232-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2016
• End date: March 08, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jose Tadeu Stefano
• Grantee: Bruna Roberta Muntanelli
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic and may evolve in the long term, to steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). There is an immediate need not only to better understand its pathogenesis, but also to develop an effective therapy to prevent progression to more severe forms, as well as, to evaluate methods that methods that enable to differentiate benign lesions from malignant, to determine tumor development phase and monitor the success of the treatments used.