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Evaluate the protein expression of cellular proliferation markers in experimental hepatic carcinogenesis secondary to non-alcoholic fat hepatic disease

Grant number: 20/06089-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2021
Effective date (End): January 31, 2022
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Claudia Pinto Marques Souza de Oliveira
Grantee:Pedro Fukui Umeta
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic and may progress, in the long run, to steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). There is an immediate need to better understand its pathogenesis, as well as to develop an effective therapy to prevent its evolution to the most severe forms. Based on these observations, we aim to evaluate the effects of a multiquinase inhibitor, sorafenib, on experimental liver carcinogenesis secondary to NAFLD. For this, we will evaluate the protein expression for glutamine synthetase, HEP-PAR-1, survivin, VEGF, VEGFR-1 and VEGFR-2, p53, EGFR and beta-catenin in an experimental model of NAFLD and HCC with and without the use of sorafenib.