Study of metabolic and molecular alterations involved in caloric restriction and hypoproteic diet in humans

• Grant number: 15/12133-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2016
• End date: December 31, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Maria Cristina Foss de Freitas
• Grantee: Rafael Ferraz Bannitz
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 18/22111-2 - Hypoglycemia and the gut microbiome, BE.EP.DR

Abstract

In recent decades, the obesity became an important public health problem, resulting in the increased prevalence of chronic diseases, such as coronary heart disease, diabetes mellitus type 2, cancer, among others. Many studies are directed to develop interventions that can block or minimize metabolic diseases induced by obesity. Among these, our group studies mechanisms and interventions able to improve metabolic control by modulating the proper functioning of the body against the damage arising from obesity mainly of diabetes mellitus type 2. The caloric restriction has been showing how a great speech on fighting metabolic diseases in different species of yeast to mammals. However data on calorie restriction in humans are not well established, requiring more complex studies in order to better understand the mechanism of action of this intervention. In conjunction with this hypothesis the hipoproteica diet is showing very effective in fighting obesity and diabetes mellitus type2. Thus, in order to define the mechanisms of action of calorie restriction and low protein diet in humans, we will submit a group of subjects with type 2 diabetes mellitus caloric restriction of 25% and another group of individuals to a low protein diet for 8 weeks and evaluate the biochemical, metabolic and molecular these interventions. In this way, we want to understand in more detail what the mechanisms of action of caloric restriction and the hipoproteica diet in humans, in order to propose less drastic interventions in combating chronic diseases associated with obesity especially diabetes mellitus type 2. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERRAZ-BANNITZ, RAFAEL; BERALDO, REBECA A.; COELHO, PRISCILA OLIVEIRA; MOREIRA, AYRTON C.; CASTRO, MARGARET; FOSS-FREITAS, MARIA CRISTINA. Circadian Misalignment Induced by Chronic Night Shift Work Promotes Endoplasmic Reticulum Stress Activation Impacting Directly on Human Metabolism. BIOLOGY-BASEL, v. 10, n. 3, MAR 2021. (15/12133-0)

FERRAZ-BANNITZ, RAFAEL; WELENDORF, CAROLINE ROSSI; COELHO, PRISCILA OLIVEIRA; SALGADO, JR., WILSON; NONINO, CARLA BARBOSA; BERALDO, REBECA A.; FOSS-FREITAS, MARIA CRISTINA. Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity. DIABETOLOGY & METABOLIC SYNDROME, v. 13, n. 1, FEB 16 2021. (15/12133-0)

FERRAZ-BANNITZ, RAFAEL; BERALDO, REBECA A.; PELUSO, A. AUGUSTO; DALL, MORTEN; BABAEI, PARIZAD; FOGLIETTI, RAYANA CARDOSO; MARTINS, LARISSA MARFORI; GOMES, PATRICIA MOREIRA; MARCHINI, JULIO SERGIO; SUEN, VIVIAN MARQUES MIGUEL; et al. Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial. NUTRIENTS, v. 14, n. 13, p. 18-pg., 2022-07-01. (15/12133-0, 17/01184-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BANNITZ, Rafael Ferraz. Study of the metabolic and molecular changes involved in caloric restriction and the hypoprotein diet in humans. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.