Evaluation the role of IL-33/IL-1beta in the control of the plasticity and heterogeneity of cellular response induced by Thalassophryne nattereri venom

• Grant number: 16/17620-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2016
• End date: October 31, 2018
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Carla Lima da Silva
• Grantee: Aline Ingrid Andrade de Barros
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Venomous fish are responsible for numerous accidents involving humans in the north and northeast regions of Brazil, Thalassophryne nattereri being the most common of them. T. nattereri venom causes chronic inflammation, impaired tissue repair and muscle necrosis in poisoned victims. In the inflammatory process, some cells such as neutrophils, monocytes and macrophages are recruited by inflammatory mediators for control and repair of the injury, but studies developed previously by our group show that the venom of T. nattereri develops an inappropriate cellular inflammatory response characterized by a reduced number of neutrophils at the site of injury. Neutrophil infiltration with subsequent apoptosis after elimination by macrophages is the prerequisite for the resolution of inflammation. IL-33 is released into the extracellular matrix after cell damage, mechanical or necrosis injury. IL-1b promotes the recruitment of neutrophils into inflamed sites. The objective of this study is to investigate the role of IL-33 and IL-1b in the control of heterogeneity and plasticity of the cellular response induced by T. nattereri venom.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, CARLA; ANDRADE-BARROS, ALINE INGRID; CARVALHO, FABIANA FRANCO; FALCAO, MARIA ALICE PIMENTEL; LOPES-FERREIRA, MONICA. Inflammasome Coordinates Senescent Chronic Wound Induced by Thalassophryne nattereri Venom. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 9, p. 20-pg., 2023-05-08. (13/07467-1, 15/17160-6, 16/15157-0, 16/17620-0)