Burden of cancer attributable to lifestyle risk factors in Brazil

• Grant number: 16/21390-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: July 01, 2017
• End date: June 30, 2018
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: José Eluf Neto
• Grantee: Leandro Fórnias Machado de Rezende
• Supervisor: Edward Giovannucci
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Harvard University, Cambridge, United States
• Associated to the scholarship: 14/25614-4 - Physical inactivity and cancer: from evaluation of etiological evidence to public health impact, BP.DR

Abstract

This proposal consists of a research internship at the Harvard T.H. Chan School of Public Health under the supervision of Professor Edward Giovannucci from July 2017 to June 2018. The work plan prioritizes the research project development, which includes knowledge exchange in preventable cases estimates, literature review, statistical analyses, and writing a manuscript. There is also an intention to attend other academic activities, such as courses and seminars, and develop further scientific investigations. The research internship project aim to deepen the analysis on the burden of cancer attributable to physical inactivity in Brazil, the main objective of the doctoral project, contextualized to the other lifestyle risk factors. Therefore, the objective of the current research project is to estimate the burden of cancer attributable to lifestyle risk factors in Brazil. We will gather lifestyle risk factors prevalence (physical inactivity, low fruit and vegetable intake, overweight, alcohol consumption, and tobacco smoking) from the most recent nationally representative health survey conducted in Brazil, Brazilian National Health Survey, 2013. The magnitude of association between lifestyle risk factors and types of cancer will be obtained from literature review. We will revise International Agency for Research on Cancer monographs and handbooks of prevention, World Cancer Research Fund reports, and search Medline, Embase e Web of Science databases to retrieve relative risks. Through this data we will estimate fractions of cancer attributable to lifestyle risk factors considering different counterfactual scenarios based on risk factor elimination (population attributable fractions - PAF) and reduction (potential impact fractions - PIF), individually and combined. Finally, to estimate number of cancer cases that could be avoided by removing/reducing lifestyle risk factors we will apply PAF/PIF estimates to number of cancer cases in Brazil, obtained from Globocan 2012. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEE, DONG HOON; MACHADO DE REZENDE, LEANDRO FORNIAS; HU, FRANK B.; JEON, JUSTIN Y.; GIOVANNUCCI, EDWARD L.. Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis. Diabetes/Metabolism Research and Reviews, v. 35, n. 2, FEB 2019. (16/21390-0, 14/25614-4)

LEE, DONG HOON; MACHADO DE REZENDE, LEANDRO FORNIAS; ELUF-NETO, JOSE; WU, KANA; TABUNG, FRED K.; GIOVANNUCCI, EDWARD L.. Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response. International Journal of Cancer, v. 145, n. 2, p. 360-369, JUL 15 2019. (16/21390-0, 14/25614-4)

MACHADO DE REZENDE, LEANDRO FORNIAS; REY-LOPEZ, JUAN PABLO; DE SA, THIAGO HERICK; CHARTRES, NICHOLAS; FABBRI, ALICE; POWELL, LAUREN; STAMATAKIS, EMMANUEL; BERO, LISA. Reporting bias in the literature on the associations of health-related behaviors and statins with cardiovascular disease and all-cause mortality. PLOS BIOLOGY, v. 16, n. 6, JUN 2018. (14/25614-4, 16/21390-0)

MACHADO DE REZENDE, LEANDRO FORNIAS; TOTARO GARCIA, LEANDRO MARTIN; MIELKE, GREGORE IVEN; LEE, DONG HOON; WU, KANA; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Preventable fractions of colon and breast cancers by increasing physical activity in Brazil: perspectives from plausible counterfactual scenarios. CANCER EPIDEMIOLOGY, v. 56, p. 38-45, OCT 2018. (16/21390-0, 14/25614-4)

MACHADO DE REZENDE, LEANDRO FORNIAS; LEE, DONG HOON; KEUM, NANA; NIMPTSCH, KATHARINA; SONG, MINGYANG; LEE, I-MIN; ELUF-NETO, JOSE; OGINO, SHUJI; FUCHS, CHARLES; MEYERHARDT, JEFFREY; et al. Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II. BRITISH JOURNAL OF CANCER, v. 121, n. 1, p. 86-94, JUL 2 2019. (16/21390-0, 14/25614-4)

MACHADO DE REZENDE, LEANDRO FORNIAS; GARCIA, LEANDRO MARTIN TOTARO; MIELKE, GREGORE IVEN; LEE, DONG HOON; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Physical activity and preventable premature deaths from non-communicable diseases in Brazil. JOURNAL OF PUBLIC HEALTH, v. 41, n. 3, p. E253-E260, SEP 2019. (16/21390-0, 14/25614-4)

LEE, DONG HOON; MACHADO DE REZENDE, LEANDRO FORNIAS; HU, FRANK B.; JEON, JUSTIN Y.; GIOVANNUCCI, EDWARD L.. Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis. DIABETES-METABOLISM RESEARCH AND REVIEWS, v. 35, n. 2, p. 9-pg., 2019-02-01. (14/25614-4, 16/21390-0)

AZEREDO, CATARINA MACHADO; DE REZENDE, LEANDRO F. M.; MALLINSON, POPPY ALICE CARSON; RICARDO, CAMILA ZANCHETA; KINRA, SANJAY; LEVY, RENATA B.; BARROS, ALUISIO J. D.. Progress and setbacks in socioeconomic inequalities in adolescent health-related behaviours in Brazil: results from three cross-sectional surveys 2009-2015. BMJ OPEN, v. 9, n. 3, JUN 2019. (16/21390-0, 14/25614-4)

MACHADO DE REZENDE, LEANDRO FORNIAS; LEE, DONG HOON; DA COSTA LOUZADA, MARIA LAURA; SONG, MINGYANG; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Proportion of cancer cases and deaths attributable to lifestyle risk factors in Brazil. CANCER EPIDEMIOLOGY, v. 59, p. 148-157, APR 2019. (16/21390-0, 14/25614-4)

MACHADO DE REZENDE, LEANDRO FORNIAS; ARNOLD, MELINA; RABACOW, FABIANA MALUF; LEVY, RENATA BERTAZZI; CLARO, RAFAEL MOREIRA; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. The increasing burden of cancer attributable to high body mass index in Brazil. CANCER EPIDEMIOLOGY, v. 54, p. 63-70, JUN 2018. (16/21390-0, 14/25614-4)