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Bacillus thuringiensis Cry1Ac interactions to brush border emebrane vesicles (BBMV) in the midgut of different larval instars of Helicoverpa armigera (Lepidoptera: Noctuidae)

Grant number: 16/21464-3
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): January 01, 2017
Effective date (End): April 30, 2017
Field of knowledge:Agronomical Sciences - Agronomy - Plant Health
Principal Investigator:Ricardo Antonio Polanczyk
Grantee:Igor Henrique Sena da Silva
Supervisor: Alejandra Bravo
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Research place: Universidad Nacional Autónoma de México, Morelos (UNAM), Mexico  
Associated to the scholarship:15/24330-5 - Interação da toxina Cry1Ac de Bacillus thurigiensis às microvilosidades apicais das células colunares (BBMVs) do intestino médio de diferentes ínstares larvais de Helicoverpa armigera (Lepidoptera: Noctuidae), BP.MS


Helicoverpa armigera is one of the most important Brazilian pest species because attacks several economically important crops even causing losses of more than 2 billion dollars annually. Due to the intensive use of pesticides to control this pest, populations have developed resistance to many chemical insecticides, and this species presents the highest number of insecticide resistance reports in the world. Thus, the use of other forms of control is necessary, as for example, microbial control with the use of the bacterium Bacillus thuringiensis (Bt), which besides its efficiency and low selection pressure which reduces the possibility of resistance, preserving the environment does not affect the natural enemies. This bacterium has been used in many countries to control this pest, either as biopesticides or in the form of transgenic plant. Among the highly toxic toxins for H. armigera, Cry1Ac stands with one of the more virulent for this insect. However, there are several reports of differences in the susceptibility of H. armigera Cry1Ac toxin in their larval instars. This variation in susceptibility to Cry1Ac toxin can be related to changes in the interaction of the toxin with receptors on the brush border membrane vesicles (BBMVs), the binding capacity of the Cry toxin to the receptors (binding reversibility) or expression of these receptors in the membrane. Thus, the objectives of this project are to evaluate the toxicity of Cry1Ac toxin in different instars of H. armigera, correlate insect susceptibility to the toxin binding capacity to its BBMVs and identify and quantify the functional receptors to Cry1Ac in different instars this pest. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SENA DA SILVA, IGOR HENRIQUE; GOMEZ, ISABEL; SANCHEZ, JORGE; MARTINEZ DE CASTRO, DIANA L.; VALICENTE, FERNANDO HERCOS; SOBERON, MARIO; POLANCZYK, RICARDO ANTONIO; BRAVO, ALEJANDRA. Identification of midgut membrane proteins from different instars of Helicoverpa armigera (Lepidoptera: Noctuidae) that bind to Cry1Ac toxin. PLoS One, v. 13, n. 12, . (15/24330-5, 16/21464-3)

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