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Pro-apoptotic effect on prostate tissue in diferent treatment methods for benign prostatic hyperplasia in dogs

Grant number: 16/10623-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Principal researcher:Camila Infantosi Vannucchi
Grantee:Caroline Bezerra Lima
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Benign prostatic hyperplasia (BPH) has a high incidence in both dogs and men. However, hormone physiology involved in the pathogenesis of BPH remains with many gaps to be elucidated. Moreover, conservative therapy with the use of finasteride for the treatment of BPH, both in men and dogs, is not yet fully established because of the possible side effects, causing controversy in their use of reproductive clinical scale. However, it is known that the use of Finasteride promotes reduction in prostate volume, and thus, the symptoms of the affected individual. Such effects occur by decrease the levels of dihydrotestosterone and consequently the activation of the apoptotic cascade, which is a form of cell death in the body, and very important for homeostasis of various systems. Hence, the objective of this work is to promote the characterization of changes resulting from benign prostatic hyperplasia in dogs undergoing treatment with finasteride , using features such as the immunohistochemistry to evaluate the expression of apoptosis factors ( Caspase3 ) and evaluate the hormone levels, measuring the main hormones involved (testosterone and dihydrotestosterone) .So, this work will contribute to further clarifications about the changes that occur with treatment of choice for benign prostatic hyperplasia in men and dogs. (AU)

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