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Characterization of seminal and hemodynamic changes in the prostate and testes of dogs with benign prostatic hyperplasia

Grant number: 13/25966-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2014
Effective date (End): February 28, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Camila Infantosi Vannucchi
Grantee:Daniel de Souza Ramos Angrimani
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):17/04102-3 - Influence of benign prostatic hyperplasia and treatment with finasteride on sperm DNA integrity in dogs, BE.EP.DR


Benign prostatic hyperplasia (BPH) is a disease of high incidence in human and canine species. However, some gaps remain not elucidated about the disease, eg, hormone physiology involved in the pathogenesis of BPH, or even a careful analysis of vascular hemodynamics involved, which can foster new tools for early diagnosis. Moreover, the therapy of choice for treatment of BPH in men and dogs, is not yet fully established before its possible side effect, causing some controversy on its use in clinical reproductive scale. Against this background , the objective of this research is to promote the characterization of changes resulting from benign prostatic hyperplasia in dogs subjected to different treatments, using resources such as Doppler ultrasonography in order to observe the hemodynamic changes involved in prostate and testicles, the technique immunohistochemistry to evaluate the expression of VEGF factor in the affected and treated prostate and histology to observe possible structural changes in the testes, and other techniques which aims to evaluate the pathophysiology of BPH, such as assessments on hormone levels, dosing the main hormones involved (testosterone, estrogen and dihydrotestosterone) and seminal level, assessing oxidative stress involved, antioxidant enzymes and parameters of semen quality. Thus, this paper hopes to contribute to greater elucidation as to the physiological aspects, clinical diagnosis and treatment of choice for benign prostatic hyperplasia in men and dogs. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANGRIMANI, DANIEL S. R.; FRANCISCHINI, MARIA CLAUDIA P.; BRITO, MAIRA M.; VANNUCCHI, CAMILA I. Prostatic hyperplasia: Vascularization, hemodynamic and hormonal analysis of dogs treated with finasteride or orchiectomy. PLoS One, v. 15, n. 6 JUN 25 2020. Web of Science Citations: 0.
ANGRIMANI, D. S. R.; SILVESTRINI, G. R.; BRITO, M. M.; ABREU, R. A.; ALMEIDA, L. L.; VANNUCCHI, I, C. Effects of benign prostatic hyperplasia and finasteride therapy on prostatic blood flow in dogs. Theriogenology, v. 114, p. 103-108, JUL 1 2018. Web of Science Citations: 3.
FLORES, R. B.; ANGRIMANI, D. S. R.; RUI, B. R.; BRITO, M. M.; ABREU, R. A.; VANNUCCHI, C. I. The influence of benign prostatic hyperplasia on sperm morphological features and sperm DNA integrity in dogs. REPRODUCTION IN DOMESTIC ANIMALS, v. 52, n. 2, SI, p. 310-315, APR 2017. Web of Science Citations: 6.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANGRIMANI, Daniel de Souza Ramos. Seminal features and hemodynamic changes of the prostate and testes of dogs with benign prostatic hyperplasia. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia São Paulo.

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