| Grant number: | 17/04102-3 |
| Support type: | Scholarships abroad - Research Internship - Doctorate |
| Effective date (Start): | April 17, 2017 |
| Effective date (End): | September 28, 2017 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Reproduction |
| Principal researcher: | Camila Infantosi Vannucchi |
| Grantee: | Daniel de Souza Ramos Angrimani |
| Supervisor abroad: | Ann Van Soom |
| Home Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Research place: | Ghent University (UGent), Belgium |
| Associated to the scholarship: | 13/25966-5 - Characterization of seminal and hemodynamic changes in the prostate and testes of dogs with benign prostatic hyperplasia , BP.DR |
Abstract Benign prostatic hyperplasia (BPH) is one of the most common diseases in canine and human males. However, some details regarding the etiopathogeny of BPH remain unclear, such as the impact of the disease on seminal quality. Moreover, the use of finasteride for the treatment of BPH in men and dogs has not yet been fully established due to the possible side effects on fertility. In humans, it is known BPH and the use of finasteride may lead to sperm alterations, such as impaired sperm DNA integrity. In dogs there are few studies focusing on the influence of the disease and consequent treatment on sperm DNA status. Therefore, the aim of this study is to characterize modifications on DNA integrity related to BPH in dogs submitted to treatment with finasteride. For this purpose, we will select twenty dogs which will be allocated to the following 2x2 factorial design: dogs affected by BPH (n = 5), dogs affected by BPH and treated with finasteride (HPB + F - n = 5), dogs free from BPH (CON - n=5), and dogs treated with finasteride (CON + F - n = 5). All evaluations will be performed at monthly intervals for 60 days starting at the beginning of therapy or diagnosis (D0, D30 and D60). Semen samples will be evaluated for the sperm DNA susceptibility to fragmentation by the Sperm Chromatic Structure Assay (SCSA) and direct evaluation of DNA fragmentation by TUNEL, chromatin dispersion test and chromomycin A3. (AU) | |
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