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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prostatic hyperplasia: Vascularization, hemodynamic and hormonal analysis of dogs treated with finasteride or orchiectomy

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Angrimani, Daniel S. R. [1] ; Francischini, Maria Claudia P. [1] ; Brito, Maira M. [1] ; Vannucchi, Camila I. [1]
Total Authors: 4
[1] Univ Sao Paulo, Fac Vet Med, Dept Anim Reprod, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: PLoS One; v. 15, n. 6 JUN 25 2020.
Web of Science Citations: 0

As a consequence of a hormonal imbalance, Prostatic Hyperplasia (PH) is characterized by increased prostate volume, along with higher local angiogenesis and vascularization. Orchiectomy is the common treatment for dogs, however it is not an option for breeding animals. Thus, finasteride arises as the drug of choice for stud dogs. Therefore, the aim of this study was to evaluate the effects of orchiectomy or finasteride therapies on hormonal and vascular dynamics of PH dogs. Fifteen dogs, aged 6-13 years were assigned to: Untreated Group (dogs diagnosed with PH-n = 5), Finasteride treated group (PH dogs treated with finasteride-n = 5) and Orchiectomy treated group (PH dogs submitted to orchiectomy-n = 5). Evaluations were performed in a monthly interval (first day of treatment; after 30 and 60 days). Doppler ultrasonography was performed to measure prostatic volume, vascularization and hemodynamic profile of prostatic artery. Dihydrotestosterone, estrogen and testosterone concentrations were measured. At day 60, prostatic biopsy was performed for histological, immunohistochemical and qPCR analysis forVEGF-Aexpression. At day 60, vascularization score was higher in untreated compared to treated groups (finasteride and orchiectomy). Furthermore,VEGF-Aexpression was lower in the Orchiectomy Treated Group, but VEGF-A was immunohistochemically lower in both treated groups (finasteride and orchiectomy) compared to the Untreated Group. The efficiency of finasteride treatment in reducing clinical signs, prostate volume and vascularization appears to be similar to orchiectomy. In conclusion, both PH medical and surgical therapy lead to reduction in prostate dimension andVEGF-Aexpression and, consequently, lower local vascularization. However, orchiectomy promotes marked hormonal changes, which ultimately lead to prostate atrophy. (AU)

FAPESP's process: 15/05419-5 - Reproductive aging in dogs: clinical and biotechnological features
Grantee:Camila Infantosi Vannucchi
Support type: Regular Research Grants
FAPESP's process: 13/25966-5 - Characterization of seminal and hemodynamic changes in the prostate and testes of dogs with benign prostatic hyperplasia
Grantee:Daniel de Souza Ramos Angrimani
Support type: Scholarships in Brazil - Doctorate