| Grant number: | 16/09364-3 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | January 01, 2017 |
| End date: | March 31, 2020 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Luiz Guilherme de Siqueira Branco |
| Grantee: | Bruna Maitan Santos |
| Host Institution: | Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| Associated scholarship(s): | 17/21796-9 - "Role of estradiol in thermoregulatory behavior and hyperalgesia in ovariectomized rats", BE.EP.DR |
Abstract Fever is by definition a regulated increase in body core temperature (Tb) in defense of the organism against pathogens. Immune system-pathogen interaction induces cytokines and prostaglandins release (inflammation mediators) that leads to activation of central regions involved in control of Tb, being anteroventral preoptic region (AVPO) hierarchically the most important region involved in thermoregulation. Systemic lipopolysaccharide (LPS - endotoxin extracted in the outer membrane of G- bacteria) administration in rats is the most used model to induce fever. Repeated LPS administration causes LPS tolerance which can be characterized by a refractory response of immune system to endotoxin, i.e, the absence of fever. The role of gaseous neuromodulators nitric oxide (NO) and carbon monoxide (CO) in LPS tolerance have been reported, but there is no evidence about the putative participation of hydrogen sulfide (H2S - another gaseous neuromodulator). The present project will test the hypothesis that H2S, endogenously produced by AVPO, participate in LPS tolerance. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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