Evaluation of wound healing properties of araticum (Annona crassiflora Mart.)in vitro

• Grant number: 16/15746-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2017
• End date: March 31, 2018
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Glaucia Maria Pastore
• Grantee: Lívia Garcia Prado
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Wound Healing is a process composed of three interdependent phases. The phases are inflammation, proliferation and remodeling. In each phase there are cells such as lymphocytes, leukocytes and macrophages, as well as mediators like cytokines. Additionally, antioxidants act combating free radicals present in the site of the injury scar and increasing the efficiency of the process through the stimulation of fibroblasts and collagen. The antioxidant compounds are present in many plants,including Annona crassiflora, popularly known as Araticum, that belongs to the Annonaceae family, and is widely used in folk medicine. This plant has a lot of phytochemical compounds and many biological properties reported in the literature. The presence of flavonoids, ascorbic acid and tannins, compounds already associated with the improvement of the healing process, reinforces the popular use of Araticum in the healing and boosts the realization of this study, which proposes characterization of the crude extract of the bark and the seed, analysis of the antioxidant capacity and evaluation of the healing ability in vitro. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PRADO, LIVIA GARCIA; ARRUDA, HENRIQUE SILVANO; PEIXOTO ARAUJO, NAYARA MACEDO; DE OLIVEIRA BRAGA, LUCIA ELAINE; BANZATO, THAIS PETROCHELLI; PEREIRA, GUSTAVO ARAUJO; FIGUEIREDO, MARIANA CECCHETTO; TASCA GOIS RUIZ, ANA LUCIA; EBERLIN, MARCOS NOGUEIRA; DE CARVALHO, JOAO ERNESTO; et al. Antioxidant, antiproliferative and healing properties of araticum (Annona crassiflora Mart.) peel and seed. Food Research International, v. 133, JUL 2020. (16/15746-6, 18/10608-0, 15/50333-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PRADO, Lívia Garcia. Evaluation of antioxidant, wound healing and anticancer activities of araticum (Annona crassiflora Mart.) in vitro. 2018. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia de Alimentos Campinas, SP.