Development and characterization of new titanium alloys for biomedical stent applications

• Grant number: 16/17502-7
• Support Opportunities: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): March 01, 2017
• Effective date (End): January 23, 2019
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Transformation Metallurgy
• Principal Investigator: Claudemiro Bolfarini
• Grantee: Athos Henrique Plaine
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 13/05987-8 - Processing and characterization of amorphous, metastable and nano-structured metallic alloys, AP.TEM

Abstract

The use of endovascular stents has a significant number of positive evidence, proving to be revolutionary in the treatment of peripheral vascular diseases. However, the materials currently used in manufacturing these medical devices are still facing questions about their long-term mechanical performance and biocompatibility, opening a path for innovation in this area. This project proposes the theoretical and experimental development of beta titanium alloys composed of non-toxic elements, including TNTZ-O alloys and metastable alloys susceptible to martensitic transition, that potentially offer the best combination of properties for the next generation of materials for stents. Alloys chemical composition will be initially defined through the DV-X± molecular orbital theory, which correlates the stability of the phases to certain electronic parameters. Subsequently, the designed alloys will be developed and processed experimentally to assess their mechanical and biological properties. Biological evaluation within a risk management process will be performed according to the set of procedures described in international standards of medical devices. Likewise, the mechanical behavior will be determined under standardized conventional and loading-unloading tensile tests, conducted mainly to evaluate the superelastic properties and radial compression resistance. At the end, this project expects to contribute, through favorable results, to improving the success of surgical procedures and extend the use of stents to a larger number of patients. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PLAINE, ATHOS HENRIQUE; DA SILVA, MURILLO ROMERO; BOLFARINI, CLAUDEMIRO. Effect of Thermo-Mechanical Treatments on the Microstructure and Mechanical Properties of the Metastable beta-type Ti-35Nb-7Zr-5Ta Alloy. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 22, n. 1, 2019. (16/17502-7)

PINOTTI, VITOR EDUARDO; PLAINE, ATHOS HENRIQUE; DA SILVA, MURILLO ROMERO; BOLFARINI, CLAUDEMIRO. Influence of oxygen addition and aging on the microstructure and mechanical properties of a beta-Ti-29Nb-13Ta-4Mo alloy. MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING, v. 819, JUL 5 2021. (16/17502-7)

PLAINE, ATHOS H.; DA SILVA, MURILLO R.; BOLFARINI, CLAUDEMIRO. Tailoring the microstructure and mechanical properties of metastable Ti-29Nb-13Ta-4.6Zr alloy for self-expansible stent applications. Journal of Alloys and Compounds, v. 800, p. 35-40, SEP 5 2019. (16/17502-7)

PLAINE, ATHOS H.; DA SILVA, MURILLO R.; BOLFARINI, CLAUDEMIRO. Microstructure and elastic deformation behavior of beta-type Ti-29Nb-13Ta-4.6Zr with promising mechanical properties for stent applications. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 8, n. 5, p. 3852-3858, SEP-OCT 2019. (16/17502-7)