Development of a protocol for new synthetic cannabinoids and NBOMe (2-(2,5-dimethoxy)-N-(2-methoxybenzyl)ethan-1-amine) derivatives) analysis in scan mode precursor ion and neutral loss by GC-MS / MS and LC-MS / MS

• Grant number: 16/23157-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2017
• End date: February 28, 2018
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Marcos Nogueira Eberlin
• Grantee: Damila Rodrigues de Morais
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Consumption, trafficking and the number of new psychoactive substances (NPS), analogues of illegal drugs of abuse produced in order to circumvent the law, has grown worldwide and concerned government agencies related to public safety. However, this has also been a public health problem, since the synthetic cannabinoids (SC), one of the most relevant NPS groups, have potentiated psychotropic effects compared to the natural cannabinoids from cannabis. In Brazil only nineteen SC were banned, until the publication of the RDC No. 87 (June 28, 2016) ANVISA which included seven distinct cannabimimetic chemical structures, greatly expanding SC list prohibited by law. The compounds of the NBOMe class are also NPS, in this case similar to LSD. In Brazil only eleven NBOMe are prohibited in accordance with the publication of RDC No. 87 (of June 28, 2016) ANVISA. However, existing methods of analysis do not have adequate sensitivity and selectivity to screening all these new CS and NBOMe prohibited by law. Since the need, the objective of this work is to develop a protocol analysis by GC-MS / MS and / or LC-MS / MS in scan mode precursor ion and neutral loss of all classes of cannabimimetic compounds and NBOMe included in previously referenced ANVISA resolution. In this context laboratory analysis it is considered an important part of an effective system against drug trafficking. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, JORDANA ALVES; SANTOS, JANDYSON MACHADO; BREITKREITZ, MARCIA CRISTINA; SANTOS FERREIRA, JOANA MARIA; PONTES LINS, PAULO MANOEL; FARIAS, SAMUEL COHEN; DE MORAIS, DAMILA RODRIGUES; EBERLIN, MARCOS NOGUEIRA; GRESPAN BOTTOLI, CARLA BEATRIZ. Characterization of the lipid profile from coconut (Cocos nucifera L.) oil of different varieties by electrospray ionization mass spectrometry associated with principal component analysis and independent component analysis. Food Research International, v. 123, p. 189-197, SEP 2019. (13/19161-4, 16/23157-0, 12/18318-4)

ARRUDA, HENRIQUE SILVANO; PEREIRA, GUSTAVO ARAUJO; DE MORAIS, DAMILA RODRIGUES; EBERLIN, MARCOS NOGUEIRA; PASTORE, GLAUCIA MARIA. Determination of free, esterified, glycosylated and insoluble-bound phenolics composition in the edible part of araticum fruit (Annona crassiflora Mart.) and its by-products by HPLC-ESI-MS/MS. Food Chemistry, v. 245, p. 738-749, APR 15 2018. (16/23157-0, 15/50333-1)

PEREIRA, GUSTAVO ARAUJO; ARRUDA, HENRIQUE SILVANO; DE MORAIS, DAMILA RODRIGUES; EBERLIN, MARCOS NOGUEIRA; PASTORE, GLAUCIA MARIA. Carbohydrates, volatile and phenolic compounds composition, and antioxidant activity of calabura (Muntingia calabura L.) fruit. Food Research International, v. 108, p. 264-273, JUN 2018. (16/23157-0, 15/50333-1)

DE MORAIS, DAMILA RODRIGUES; BARBOSA, INGRID LOPES; CUNHA, KELLY FRANCISCO; TRIPODI, GUILHERME LUCAS; FIGUEIREDO ANGOLINI, CELIO FERNANDO; FRANCO, MARCOS FERNANDO; DE AQUINO, ELVIS MEDEIROS; EBERLIN, MARCOS NOGUEIRA; COSTA, JOSE LUIZ. EASI-IMS an expedite and secure technique to screen for 25I-NBOH in blotter papers. Journal of Mass Spectrometry, v. 52, n. 10, p. 701-706, OCT 2017. (16/23157-0, 15/10650-8)

DE MORAIS, DAMILA RODRIGUES; LANARO, RAFAEL; BARBOSA, INGRID LOPES; SANTOS, JANDYSON MACHADO; CUNHA, KELLY FRANCISCO; HERNANDES, VINICIUS VERI; TESSARO, ELIAS PAULO; GOMES, CEZAR SILVINO; EBERLIN, MARCOS NOGUEIRA; COSTA, JOSE LUIZ. Ayahuasca and Kambo intoxication after alternative natural therapy for depression, confirmed by mass spectrometry. Forensic Toxicology, v. 36, n. 1, p. 212-221, JAN 2018. (15/10650-8, 16/23157-0)

DE MORAIS, DAMILA RODRIGUES; DA CUNHA, KELLY FRANCISCO; RODRIGUES, TAIS BETONI; LANARO, RAFAEL; BARBOSA, LILIAN DE MELO; ZACCA, JORGE JARDIM; EBERLIN, MARCOS NOGUEIRA; COSTA, JOSE LUIZ. Triple quadrupole-mass spectrometry protocols for the analysis of NBOMes and NBOHs in blotter papers. Forensic Science International, v. 309, APR 2020. (18/00432-1, 16/23157-0, 18/11849-0)