Advanced search
Start date
Betweenand

Biocompatibility analysis of PMMA-TiO2 and PMMA-ZrO2 organic-inorganic hybrids coatings deposited on Ti6Al4V titanium alloy

Grant number: 17/02899-1
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 01, 2017
Effective date (End): July 31, 2018
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal researcher:Peter Hammer
Grantee:Samarah Vargas Harb
Supervisor abroad: Ali Khademhosseini
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: Harvard University, Cambridge, United States  
Associated to the scholarship:15/09342-7 - Development of multifunctional PMMA- (TiO2, ZrO2 and CeO2)hybrids, BP.DR

Abstract

Using the sol-gel process organic-inorganic hybrids will be synthesized consisting of poly(methyl methacrylate) (PMMA) covalently bonded to TiO2 and ZrO2 inorganic phases through the coupling agent 2-hydroxyethyl methacrylate (HEMA). PMMA-TiO2 and PMMA-ZrO2 hybrids coatings will be deposited onto Ti6Al4V titanium alloy by dip-coating aiming to obtain multifunctional hybrids systems that combine properties such as high mechanical strength, thermal stability, anticorrosive characteristics and biocompatibility. The syntheses of the nanocomposites involve sol-gel reactions of titanium isopropoxide or zirconium propoxide, and subsequent radical polymerization of different fractions of HEMA and methyl methacrylate (MMA), using benzoyl peroxide (BPO) as thermal initiator. The structural, thermal and electrochemical characterization of the hybrids will be performed at the Chemistry Institute (UNESP) and will be presented in the annual report. During the internship at the Harvard University the activities will involve the biological characterization of PMMA-TiO2 and PMMA-ZrO2 films employing organ-on-a-chip devices to evaluate their biocompatibility for implant applications. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AFEWERKI, SAMSON; BASSOUS, NICOLE; HARB, SAMARAH VARGAS; CORAT, MARCUS ALEXANDRE F.; MAHARJAN, SUSHILA; RUIZ-ESPARZA, GUILLERMO U.; DE PAULA, MIRIAN M. M.; WEBSTER, THOMAS J.; TIM, CARLA ROBERTA; VIANA, BARTOLOMEU CRUZ; WANG, DANQUAN; WANG, XICHI; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Engineering multifunctional bactericidal nanofibers for abdominal hernia repair. COMMUNICATIONS BIOLOGY, v. 4, n. 1 FEB 19 2021. Web of Science Citations: 0.
HARB, V, SAMARAH; BASSOUS, NICOLE J.; DE SOUZA, THIAGO A. C.; TRENTIN, ANDRESSA; PULCINELLI, SANDRA H.; SANTILLI, V, CELSO; WEBSTER, THOMAS J.; LOBO, ANDERSON O.; HAMMER, PETER. Hydroxyapatite and beta-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants. Materials Science & Engineering C-Materials for Biological Applications, v. 116, NOV 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.