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Development of microfluidic paper-based analytical device for clinical interest analysis with fluorescence detection

Grant number: 16/20847-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2017
Effective date (End): February 29, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Helena Redigolo Pezza
Grantee:Eduardo Luiz Rossini
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):18/05993-1 - Paper-spray mass spectrometry as a tool for doping detection, BE.EP.DR


Nanotechnology is a multidisciplinary science that includes scientific and technological activities in the nanometer scale, which includes materials with length between 1 and 100 nm in at least one dimension. Quantum dots are nanoparticles capable to emitting light in the visible region, when excited with electromagnetic radiation of higher energy than the emitted. Quantum dots have wide applicability, more specifically carbon quantum dots (C-dots), which besides the traditional inorganic QDs properties, such as luminescence dependent of the size and wavelength, photodegradation resistance and easy bioconjugation, the C-dots have no intrinsic toxicity, which facilitates application in biological samples, and they are consistent with the philosophy of Green Chemistry. The biocompatibility of C-dots is of great interest for application in clinical analysis, as the dosage of various analytes like glucose, uric acid, creatinine, lactate, among others, provide important information such as renal function, cardiac disease and diabetes. In addition, with the use of microfluidic devices on paper are developed fast test, accurate, easy to use, sensitive, using reagent and sample volumes reduced and deliverable to those who need them, which is consistent with that proposed by the World Health Organization. In this way, the development of µPAD for simultaneous determination of clinical interest compounds using the same fluorescent reagent consisting of carbon quantum dots will be studied.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSSINI, EDUARDO LUIZ; MILANI, MARIA IZABEL; LIMA, LILIANE SPAZZAPAM; PEZZA, HELENA REDIGOLO. Paper microfluidic device using carbon dots to detect glucose and lactate in saliva samples. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 248, MAR 5 2021. Web of Science Citations: 0.
ROSSINI, EDUARDO LUIZ; MILANI, MARIA IZABEL; PEZZA, HELENA REDIGOLO. Green synthesis of fluorescent carbon dots for determination of glucose in biofluids using a paper platform. Talanta, v. 201, p. 503-510, AUG 15 2019. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ROSSINI, Eduardo Luiz. Análises em dispositivos de papel : síntese de carbon dot aplicada à determinação de compostos de interesse clínico e paper-spray ionization para detecção direta de doping esportivo. 2020. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Química..

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