Development of vanguard analytical methods using spot test and paper-based microfluidic device

• Grant number: 15/21733-1
• Support type: Regular Research Grants
• Duration: June 01, 2016 - November 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Helena Redigolo Pezza
• Grantee: Helena Redigolo Pezza
• Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Nowadays, the development of rapid, simple and inexpensive analytical methods is of growing interest, especially since fast decisions are often needed in the medical diagnostic, and forensic, environmental, and industrial chemistry field. In addition, in the development of a new analytical method the amounts and toxicities of the reagents used, and the wastes produced, are as important as any other analytical feature. Spot tests using microfluidic-paper platform, coupled with diffuse reflectance spectroscopy or digital images, minimize use of reagents/solvents makes them very useful for the development of analytical methods that address the notion of Green Chemistry. The use of filter paper platform provides a good surface for spot tests, is very inexpensive, and is manufactured from renewable and recyclable resources.In this study we intend to continue the activities of the research group investigate the development of environmental friendly method by spot test/reflectance detection using paper-based microfluidic devices and/or other paper-based detection platforms with the goal to improve the detection limit and sensitivity for clinical and diagnostic, forensic, and food analysis applications. Paper-based microfluidic devices or other paper-based platforms are emerging fields of research. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, LILIANE SPAZZAPAM; ROSSINI, EDUARDO LUIZ; PEZZA, LEONARDO; PEZZA, HELENA REDIGOLO. Bioactive paper platform for detection of hydrogen peroxide in milk. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 227, FEB 15 2020. Web of Science Citations: 0.

ROSSINI, EDUARDO LUIZ; MILANI, MARIA IZABEL; PEZZA, HELENA REDIGOLO. Green synthesis of fluorescent carbon dots for determination of glucose in biofluids using a paper platform. Talanta, v. 201, p. 503-510, AUG 15 2019. Web of Science Citations: 3.

MARQUES LUIZ, VITOR HUGO; LIMA, LILIANE SPAZZAPAM; ROSSINI, EDUARDO LUIZ; PEZZA, LEONARDO; PEZZA, HELENA REDIGOLO. Paper platform for determination of bumetanide in human urine samples to detect doping in sports using digital image analysis. Microchemical Journal, v. 147, p. 43-48, JUN 2019. Web of Science Citations: 2.

CATELANI, TIAGO AUGUSTO; BITTAR, DAYANA BORGES; PEZZA, LEONARDO; PEZZA, HELENA REDIGOLO. Determination of amino acids in gym supplements using digital images and paper platform coupled to diffuse reflectance spectroscopy and USB device. Talanta, v. 196, p. 523-529, MAY 1 2019. Web of Science Citations: 2.

POLLI SILVESTRE, AMANDA LETICIA; MILANI, MARIA IZABEL; ROSSINI, EDUARDO LUIZ; PEZZA, LEONARDO; PEZZA, HELENA REDIGOLO. A paper platform for colorimetric determination of aluminum Chink fer hydrochloride in antiperspirant samples. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 204, p. 432-435, NOV 5 2018. Web of Science Citations: 0.

ROSSINI, EDUARDO LUIZ; MILANI, MARIA IZABEL; CARRILHO, EMANUEL; PEZZA, LEONARDO; PEZZA, HELENA REDIGOLO. Simultaneous determination of renal function biomarkers in urine using a validated paper-based microfluidic analytical device. Analytica Chimica Acta, v. 997, p. 16-23, JAN 2 2018. Web of Science Citations: 16.

DE TOLEDO, PAULO R. A. B.; TOCI, ALINE T.; PEZZA, HELENA R.; PEZZA, LEONARDO. Fast and simple method for identification of adulteration of cow's milk with urea using diffuse reflectance spectroscopy. ANALYTICAL METHODS, v. 9, n. 45, p. 6357-6364, DEC 7 2017. Web of Science Citations: 2.

MILANI, MARIA IZABEL; ROSSINI, EDUARDO LUIZ; CASTOLDI, KARINE; PEZZA, LEONARDO; PEZZA, HELENA REDIGOLO. Paper platform for reflectometric determination of furfural and hydroxymethylfurfural in sugarcane liquor. Microchemical Journal, v. 133, p. 286-292, JUL 2017. Web of Science Citations: 1.

BUENO TOLEDO, PAULO ROBERTO A.; TOCI, ALINE THEODORO; PEZZA, HELENA REDIGOLO; PEZZA, LEONARDO. Green Determination of Urea in Moisturizers by Diffuse Reflectance Spectroscopy. Analytical Letters, v. 50, n. 12, p. 2030-2043, 2017. Web of Science Citations: 0.