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Paper-spray mass spectrometry as a tool for doping detection

Grant number: 18/05993-1
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2018
Effective date (End): September 30, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Helena Redigolo Pezza
Grantee:Eduardo Luiz Rossini
Supervisor abroad: Abraham Badu-Tawiah
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: Ohio State University, Columbus, United States  
Associated to the scholarship:16/20847-6 - Development of microfluidic paper-based analytical device for clinical interest analysis with fluorescence detection, BP.DR


Paper is been used successfully in analytical determinations in the past decades; it is a cheap, available, biocompatible and renewable raw material. Paper has several different applications, such as paper chromatography, paper-strip, lateral flow assay, electrophoresis, flow chemistry and mass spectrometry. Paper-spray mass spectrometry (PS-MS) is an ambient ionization method that combines the advantages of the paper platform with the reliability of MS analysis, reducing the consumption of time, reagent, and organic solvent. The use of illicit substances to improve enhance athletic performance in sport is forbidden and considered doping. The anti-doping test is applied in the Olympic Games since 1968 edition and several compounds, such as anabolic steroids, diuretics, stimulants, and narcotics are determined in biofluids by this test. Therefore, it seems necessary to develop a rapid, robust, reliable, efficient and sample preparation free PS-MS method for illicit substance in biofluids. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSSINI, EDUARDO LUIZ; KULYK, DMYTRO S.; ANSU-GYEABOURH, EMELIA; SAHRAEIAN, TAGHI; PEZZA, HELENA REDIGOLO; BADU-TAWIAH, ABRAHAM K. Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, v. 31, n. 6, p. 1212-1222, JUN 3 2020. Web of Science Citations: 0.

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