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Effects of aging and of physical activity upon autophagy in hippocampus, substantia nigra and locus coeruleus

Grant number: 16/20109-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2017
Effective date (End): July 31, 2018
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Merari de Fátima Ramires Ferrari
Grantee:Natália Fagundes Borges Teruel
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Neurodegenerative processes are closely associated with aging. Biomolecular changes that accompany the aging process induce protein deposits related to diseases such as Alzheimer's, Parkinson's and Amyotrophic Lateral Sclerosis. In addition, practice of moderate physical activity may ameliorate neurodegeneration. The analysis of the expression of proteins associated with autophagy Beclin-1, P62, HDAC6, LC3-I and LC3-II, Pink-1, Parkin and Miro-1, using Western Blotting technique, in hippocampus, substantia nigra and locus coeruleus tissues from 2 months old and 11 months old male Lewis rats, these last ones submitted or not to treadmill running, seeks a better understanding of the relation between aging and neurodegeneration. (AU)