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Synthesis and characterization of hydrogel of poly (N-VINYL-2-PYRROLIDONA) with laponite RD clay to modulate NEOMYCIN/NANO silver drug delivery

Grant number: 16/19254-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2017
Effective date (End): March 31, 2019
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Duclerc Fernandes Parra
Grantee:Vinicius Juvino dos Santos
Host Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil


Hydrogels are biomaterials widely used in the biomedical field. Have ability to absorb large quantities of fluids without losing its physical integrity. Those materials consist of a three dimensional cross-linked polymer which is formed by physical or chemical bonds. Hydrogels chemically cross-linked can be produced by radiation of polymers in aqueous solution. Hydrogels have been recently applied as trans-dermal wound dressings with drug delivery systems. These materials provide ideal conditions for treatment of topical wounds, as it keeps the wound environment moisturized promoting autoclitic debridement, accelerating healing, absorb exudate and still release drug in a controlled way. The poly (N-vinyl-2-pyrrolidone) (PVP) is a polymer which once irradiated in aqueous solution forms hydrogel. In order to improve the properties, to the PVP will be added, a plasticizer polymer as Poly ethylene glycol; a gelling agent as Ágar; and an inorganic filler as Laponite RD clay for improvement of physicochemical and mechanical properties of hydrogels. Finally neomycin sulfate and nano silver will be incorporated into the hydrogel for test drug release. Hydrogels will be characterized by swelling analysis, gel fraction analysis Thermogravimetry (TG), Differential Scanning Calorimetry (DSC), diffraction X-ray (XRD), Scanning Electron Microscopy (SEM) / Energy Dispersive Spectroscopy (EDS) , transmission electron microscopy (TEM), mechanical tensile tests, analysis of drug release in vitro via HPLC-MS/MS, cytotoxicity assay and bactericidal activity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMPOS, LUIZA M. P.; BOARO, LETICIA C.; SANTOS, TAMIRIS M. R.; SANTOS, VINICIUS J.; GRECCO-ROMANO, REBECA; SANTOS, MARIANA J.; PARRA, DUCLERC F.. Polymerization shrinkage evaluation in experimental dental composite filled with montmorillonite nanoparticles. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 131, n. 1, p. 771-774, . (16/19254-0, 13/07229-3)
ZAFALON, ANGELICA TAMIAO; JUVINO, VINICIUS DOS SANTOS; KOMATSU, LUIZ GUSTAVO HIROKI; PARRA, DUCLERC FERNANDES; LUGAO, ADEMAR; SAMUEL, TEMESGEN; RANGARI, VIJAYA; LI, B; LI, J; IKHMAYIES, S; et al. Synthesis and Characterization of PVP/CaCO3-Ag Blend Hydrogel by Gamma Irradiation: Study of Drug Delivery System and Antimicrobial Activity. CHARACTERIZATION OF MINERALS, METALS, AND MATERIALS 2019, v. N/A, p. 11-pg., . (16/19254-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Vinicius Juvino dos. Synthesis and characterization of poly (n-vinyl-2-pyrrolidone) hydrogels containing nano silver and laponite RD clay for modulation of neomycin release. 2019. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Pesquisas Energéticas e Nucleares (IPEN/BT) São Paulo.

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