Avoidance and threat-related disorders

• Grant number: 16/24681-5
• Support Opportunities: Scholarships abroad - Research
• Effective date (Start): July 01, 2017
• Effective date (End): June 30, 2018
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Valor Concedido/Desembolsado (R$): 131,955.95 / 131,955.95
• Principal Investigator: Felipe D Alessandro Ferreira Corchs
• Grantee: Felipe D Alessandro Ferreira Corchs
• Host Investigator: Daniela Schiller
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Research place: Icahn School of Medicine at Mount Sinai, United States

Abstract

Anxiety disorders, as well as trauma- and stress-related disorders have been understood as psychiatric conditions related to biobehavioral mechanisms involved in defense against threats. Avoidance is considered a major point involved in both the genesis and treatment of these disorders, but research in this area was neglected for decades, especially in clinical populations. More recently, however, the development of the knowledge upon reflexive defensive behaviors in these disorders has been so huge and promising to the development of knowledge in clinical population, that the motivation to study operant learning in these subjects, especially escape and avoidance, has risen again. In this context, the present project aims to explore the characteristics of avoidance learning in subjects with threat-related disorders, by means of an active avoidance protocol. Thus, the avoidance pattern observed in the clinical population will be compared against the controls and the clinical sample will be explored internally in order to find subgroups of disorders. These data would be of great value to movement of reorganization of psychiatric conditions that is currently in progress.