Antimicrobial activity of bioactive glass against multiresistant osteomyelitis-causing bacteria: an in vitro study

• Grant number: 16/20416-5
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): March 01, 2017
• Effective date (End): December 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Mauro José Costa Salles
• Grantee: Mateus Trinconi Cunha
• Home Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil

Abstract

Bioactive Glasses (BAG) are the newest materials studied for the adjunctive treatment of osteomyelitis, especially for their osteoconductive, angiogenic, and, most of all, antimicrobian activities, setting them apart of currently available materials. This study is an in vitro analysis of the antimicrobian activity of BAG compared to Polymethyl methacrylate (PMMA), which is, currently, the most widely used material during the surgical treatment of osteomyelitis. In vitro antibacterial activity of BAG-S53P4 against osteomyelitis-derived bacterial isolates stored Santa Casa de São Paulo was evaluated by means of time kill curves, with colony counts performed after 24, 48 and 72 hours of incubation. Differences in colonies counts between BAG-S53P4 and inert glass were evaluated by means of two-way analysis of variance (ANOVA) and Bonferroni's t test. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CUNHA, MATEUS TRINCONI; MURCA, MARIA APARECIDA; NIGRO, STANLEY; KLAUTAU, GISELLE BURLAMAQUI; SALLES, MAURO JOSE COSTA. In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection. BMC INFECTIOUS DISEASES, v. 18, APR 3 2018. Web of Science Citations: 1.