Histopathological correlates of magnetic resonance imaging in patients with drug-resistant epilepsies

• Grant number: 17/03739-8
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: June 01, 2017
• End date: May 31, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: João Pereira Leite
• Grantee: José Eduardo Peixoto Santos
• Supervisor: Ingmar Blumcke
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany
• Associated to the scholarship: 15/20840-9 - Histopathological correlates of magnetic resonance imaging in patients with drug-resistant epilepsies, BP.PD

Abstract

Magnetic resonance imaging (MRI) is an important non-invasive tool for the evaluation of several conditions. In drug-resistant epilepsies, surgical outcome depends largely on complete removal of the epileptogenic region, making MRI crucial for surgical planning. Cortical dysplasias, one of the most common pathological findings in young drug-resistant patients, can remain undetected by MRI, even using the most modern protocols in 3T machines. Consequently, a significant percentage of patients fail to achieve postsurgical seizure control. Thereby, it is important to optimize MRI to detect more subtle pathological changes as well as to define the specific pathological substrates of the MR signals. Our aim with the present research proposal is to identify the histologic substrates of the different MRI protocols, and to improve the detection of cortical dysplasias by quantitative higher field (3T and 7T) MRI.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEIXOTO-SANTOS, JOSE EDUARDO; BLUMCKE, INGMAR. Neuropathology of the 21st century for the Latin American epilepsy community. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, v. 90, n. SI, p. 51-59, AUG 2021. (17/03739-8)

SAUTE, RICARDO LUTZKY; PEIXOTO-SANTOS, JOSE EDUARDO; VELASCO, TONICARLO R.; LEITE, JOAO PEREIRA. Improving surgical outcome with electric source imaging and high field magnetic resonance imaging. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, v. 90, n. SI, p. 145-154, AUG 2021. (17/03739-8, 16/17882-4)

PEIXOTO-SANTOS, JOSE EDUARDO; DRUMOND DE CARVALHO, LUCIANA ESTEFANI; KANDRATAVICIUS, LUDMYLA; BESERRA DINIZ, PAULA REJANE; SCANDIUZZI, RENATA CALDO; CORAS, ROLAND; BLUEMCKE, INGMAR; ASSIRATI, JOAO ALBERTO; CARLOTTI, CARLOS GILBERTO; MARCONATO SIMOES MATIAS, CAIO CESAR; et al. Manual Hippocampal Subfield Segmentation Using High-Field MRI: Impact of Different Subfields in Hippocampal Volume Loss of Temporal Lobe Epilepsy Patients. FRONTIERS IN NEUROLOGY, v. 9, NOV 20 2018. (17/03739-8, 15/20840-9, 16/17882-4)

RAMPP, STEFAN; ROSSLER, KARL; HAMER, HAJO; ILLEK, MARGIT; BUCHFELDER, MICHAEL; DOERFLER, ARND; PIEPER, TOM; HARTLIEB, TILL; KUDERNATSCH, MANFRED; KOELBLE, KONRAD; et al. Dysmorphic neurons as cellular source for phase-amplitude coupling in Focal Cortical Dysplasia Type II. CLINICAL NEUROPHYSIOLOGY, v. 132, n. 3, p. 782-792, MAR 2021. (17/03739-8)