Effect of systemic inflammation following ischemia / reperfusion upon the visceral adipose tissue of mice

• Grant number: 16/17640-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2017
• End date: August 31, 2018
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Alessandra Gambero
• Grantee: Lígia Fernanda Ferraz
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

Ischemia and reperfusion develops when there is an obstruction of blood vessels with subsequent restoration of flow, and its occurs in cases of myocardial ischemia, shock, trauma, hemorrhagic injury, surgery and transplantation. During hepatic ischemia, for example, there is production of free radicals that activate Kuppfer cells (macrophages residing in the liver) resulting in proinflammatory cytokines production. With reperfusion, neutrophils and macrophages are additionally recruited to the liver leading to an increased in the production of proinflammatory cytokines reaching the systemic circulation and triggering an inflammatory response that affects remote organs like lungs, kidneys, intestine, pancreas, adrenal and heart . Although it is well established that adipose tissue is inflamed during obesity and contributes to the establishment of a chronic low grade systemic inflammation, little is known about the effects of systemic inflammation on adipose tissue or if the pre-injured adipose tissue by obesity would respond the same way or if the adipose tissue also contribute to systemic inflammation that follows the injury of ischemia and reperfusion. Thus, this project aims to study the effects of systemic inflammation (injury by ischemia / reperfusion) on visceral adipose tissue in mice, evaluating the local inflammatory response (infiltration of leukocytes, expression of adhesion molecules, cytokine production) and the adipose tissue contribution to the maintenance of systemic inflammation. It is also intended to assess whether obese adipose tissue promote the same answers. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIGIA FERNANDA FERRAZ; CINTIA RABELO E PAIVA CARIA; RAQUEL DE CÁSSIA SANTOS; MARCELO LIMA RIBEIRO; ALESSANDRA GAMBERO. Effects of systemic inflammation due to hepatic ischemia-reperfusion injury upon lean or obese visceral adipose tissue. Acta Cirurgica Brasileira, v. 37, n. 1, 2022-03-14. (16/17640-0)