Characterization, molecular profile, virulence and multidrug resistance factors in strains of Escherichia coli isolated from Bovine Mastitis with different scores

• Grant number: 17/08102-8
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: May 01, 2017
• End date: July 31, 2019
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: Marcio Garcia Ribeiro
• Grantee: Simony Trevizan Guerra
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 15/19688-8 - E. coli, Klebsiella pnemoniae and Enterococcus spp: impact of virulence factors in bovine mastitis and public health concern, AP.TEM

Abstract

Escherichia coli (E. coli) is the main pathogen involved in the etiology of Bovine Mastitis from the environmental origin. Mammary infections by E. coli exhibit a wide range of clinical signs causing only milk anormalites (score 1), milk and inflammatory changes of the mammary gland (score 2) and significant systemic signs (score 3). E. coli belongs to the normal gut microflora of humans and animals and exhibits considerable variety of virulence properties. However, the profile of virulence factors that influenciate the severity scores of bovine clinical mastitis remains not fully understood. In this scenario, the present study intends to investigate both the occurrence of genes associated to the virulence of extraintestinal E. coli (ExPEC) and genes related to the different E. coli pathophypes, the classification in the phylogenetic groups, the presence of motility and the profile of antimicrobial resistance in E. coli strains isolated from Bovine Mastitis with different scores. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUERRA, SIMONY T.; ORSI, HENRIQUE; JOAQUIM, SAMEA F.; GUIMARAES, FELIPE F.; LOPES, BRUNA C.; DALANEZI, FELIPE M.; LEITE, DOMINGOS S.; LANGONI, HELIO; PANTOJA, JOSE C. F.; RALL, VERA L. M.; et al. Short communication: Investigation of extra-intestinal pathogenic Escherichia coli virulence genes, bacterial motility, and multidrug resistance pattern of strains isolated from dairy cows with different severity scores of clinicalmastitis. JOURNAL OF DAIRY SCIENCE, v. 103, n. 4, p. 3606-3614, APR 2020. (15/19688-8, 17/08102-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GUERRA, Simony Trevizan. Antimicrobial resistance and virulence of E. coli strains isolated from bovine mastitis with different clinical scores. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu Botucatu.