Caquexia in non-small cell lung cancer patient: physical fitness influence on prognosis

• Grant number: 16/20187-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2017
• End date: February 28, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Gilberto de Castro Junior
• Grantee: Willian das Neves Silva
• Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated scholarship(s): 19/17009-7 - Identifying the mechanisms behind loss of muscle function in non-small cell lung cancer patients, BE.EP.DR

Abstract

Non-small-cell lung cancer (NSCLC) is currently the neoplasm leading in deaths worldwide and in Brazil it figures as the second most common cancer in terms of number of deaths. Patients are usually diagnosed in advanced stages and, consequently, more than 45% of all patients are diagnosed with cachexia, characterized by a severe loss of muscle mass with or without fat loss. This syndrome is characterized by inflammation, severe loss of muscle contractile proteins, leading to fatigue and increased mortality. Furthermore, patients with cachexia usually do present lower response rates to anticancer treatments and is also associated with a worse overall prognosis. Therefore, treatments directed to mitigate muscle loss in these patients are awaited. Cohort studies do suggest a significant positive impact of physical fitness and prognosis in different chronic diseases; however its impact in advanced NSCLC patients is not clear. Here our aim is to better understand the relationship between physical fitness variables (muscle and cardiorespiratory function, body composition and daily physical activity level) with prognosis and mortality in a group of NSCLC patients, as well as to study the effect of chemotherapy on these variables. Sixty NSCLC patients will be accrued. We will assess the maximum oxygen consumption, daily physical activity, muscle function, muscle morphology, anxiety, depression, performance status and fatigue in the baseline, after chemotherapy and 3 months after. The prognostic impact of these physical fitness variables will be defined, as well as their predictive value in terms of response to anticancer treatments in advanced NSCLC patients. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES, CHRISTIANO R. R.; NEVES, WILLIAN DAS; ALMEIDA, NEY R. DE; EICHELBERGER, ERIC J.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; BECHARA, LUIZ R. G.; FARIA, DANIELE DE PAULA; ALVES, MARIA J. N.; et al. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/ TRIP15/ALIEN. MOLECULAR METABOLISM, v. 39, SEP 2020. (16/50336-3, 12/02528-0, 14/03016-8, 12/25240-1, 15/22814-5, 16/01478-0, 16/20187-6)

ALVES, CHRISTIANO R. R.; EICHELBERGER, ERIC J.; DAS NEVES, WILLIAN; RIBEIRO, MARCIO A. C.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; DE ALMEIDA, NEY R.; HAGEN, LARS; SHARMA, ANIMESH; FERREIRA, JULIO C. B.; et al. Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. FASEB JOURNAL, v. 35, n. 7, JUL 2021. (16/50336-3, 16/01478-0, 12/25240-1, 16/20187-6, 15/22814-5, 14/03016-8, 12/02528-0)

CUNHA, MATEUS TRINCONI; DE SOUZA BORGES, ANA PAULA; JARDIM, VINICIUS CARVALHO; FUJITA, ANDRE; DE CASTRO JR, GILBERTO. Predicting survival in metastatic non-small cell lung cancer patients with poor ECOG-PS: A single-arm prospective study. CANCER MEDICINE, v. N/A, p. 11-pg., 2022-09-26. (15/22814-5, 16/20187-6, 18/21934-5, 19/03615-2)

DE CASTRO, G., JR.; DAS NEVES SILVA, W.; BORGES, A. P. D. S.; JARDIM, V. C.; BRUM, P. C. B. C.; FUJITA, A.. Impact of systemic inflammation, intramuscular adipose tissue content, and EORTC-QLQ-CAX24 symptom scale on the prognosis of patients with advanced non-small-cell lung cancer. Annals of Oncology, v. 31, p. 1-pg., 2020-09-01. (15/22814-5, 16/20187-6)

ALVES, CHRISTIANO R. R.; DAS NEVES, WILLIAN; DE ALMEIDA, NEY R.; EICHELBERGER, ERIC J.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; BECHARA, LUIZ R. G.; FARIA, DANIELE DE PAULA; ALVES, MARIA J. N.; et al. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. MOLECULAR METABOLISM, v. 39, p. 17-pg., 2020-09-01. (16/50336-3, 14/03016-8, 16/20187-6, 12/25240-1, 16/01478-0, 15/22814-5, 12/02528-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Willian das Neves. Cachexia in non-small lung cancer cell patients: influence of physical fitness on prognosis. 2022. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.