The use of magnetic resonance imaging in the quantitative study of bone microarchitecture and its relatioship with the accumulation of muscle and bone marrow adipose tissue in DM2

• Grant number: 16/18574-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2017
• End date: February 28, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Francisco José Albuquerque de Paula
• Grantee: Iana Mizumukai de Araujo
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Bone fragility was recently recognized as one of the complications of type 2 diabetes mellitus (DM2). Bone mass in DM2 is normal or elevated when compared with a control group, and bone fragitily may be related with impairments in bone quality. Bone densitometry, even considered as a golden standard in the evaluation of bone density, does not reveal parameters related with bone quality. Thus, there is a need to explore other tools that could unveil such measeurements. Magnetic resonance imaging (MRI) is a technique capable of quantifying bone marrow adipose tissue (MAT) and apparent trabecular volume (appTV). MAT is considered as an important parameter related negatively with with bone mass, for instance, in anorexia nervosa and osteoporosis. Given that bone fragility in DM2 is a consequence which takes to increase of morbidity and mortality, it is important to identify risk groups in order to prevent fractures. To that aim, exams like lumbar spine and muscle MRI spectroscopy, bone marrow adiposity measurements by spectroscopy, and MRI trabecular imaging in proximal tibia will be accomplished to elucidade the role of body fat distribution in bone mass parameters. Bone densitometry will be carried out to quantify bone mass and also body composition of patients and controls. Biochemical exams will identify factor which may intervene in the fat overflow from adipose tissue into muscle and bone marrow. Also, these exams will be useful to identify alteration of secreted factors by these same systems. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS JR, JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; SALMON, CARLOS E. G.; ALBUQUERQUE DE PAULA, FRANCISCO JOSE. Osteoporosis and Hepatic Steatosis: 2 Closely Related Complications in Short-Bowel Syndrome. Journal of Parenteral and Enteral Nutrition, FEB 2020. (18/14060-9, 16/18574-1)

DE ARAUJO, I. M.; PARREIRAS-E-SILVA, L. T.; CARVALHO, A. L.; ELIAS, JR., J.; SALMON, C. E. G.; DE PAULA, F. J. A.. Insulin resistance negatively affects bone quality not quantity: the relationship between bone and adipose tissue. OSTEOPOROSIS INTERNATIONAL, v. 31, n. 6, FEB 2020. (18/14060-9, 16/18574-1)

ALENCAR, M. A. V. S. D.; DE ARAUJO, I. M.; PARREIRAS-E-SILVA, L. T.; NOGUEIRA-BARBOSA, M. H.; SALGADO JR, W.; ELIAS JR, J.; SALMON, C. E. G.; DE PAULA, F. J. A.. Hashtag bone: detrimental effects on bone contrast with metabolic benefits one and five years after Roux-en-Y gastric bypass. Brazilian Journal of Medical and Biological Research, v. 54, n. 12, 2021. (16/18574-1, 18/18071-5)

BATISTA, SERGIO LUCHINI; DE ARAUJO, IANA MIZUMUKAI; CARVALHO, ADRIANA LELIS; ALENCAR, MARIA AUGUSTA V. S. D.; NAHAS, ANDRESSA K.; ELIAS JR, JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SALMON, CARLOS E. G.; ELIAS, PAULA C. L.; MOREIRA, AYRTON C.; et al. Beyond the metabolic syndrome: Visceral and marrow adipose tissues impair bone quantity and quality in Cushing's disease. PLoS One, v. 14, n. 10, OCT 15 2019. (16/18574-1, 18/14060-9)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS, JORGE, JR.; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; BONELLA, JESSICA; NAHAS, ANDRESSA K.; SALMON, CARLOS E. G.; DE PAULA, FRANCISCO J. A.. Short bowel syndrome: influence of nutritional therapy and incretin GLP1 on bone marrow adipose tissue. Annals of the New York Academy of Sciences, v. 1415, n. 1, p. 10-pg., 2018-03-01. (16/18574-1, 14/15864-3)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS, JR., JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; BONELLA, JESSICA; NAHAS, ANDRESSA K.; SALMON, CARLOS E. G.; DE PAULA, FRANCISCO J. A.. Short bowel syndrome: influence of nutritional therapy and incretin GLP1 on bone marrow adipose tissue. Annals of the New York Academy of Sciences, v. 1415, n. 1, SI, p. 47-56, MAR 2018. (14/15864-3, 16/18574-1)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS JR, JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; SALMON, CARLOS E. G.; ALBUQUERQUE DE PAULA, FRANCISCO JOSE. Osteoporosis and Hepatic Steatosis: 2 Closely Related Complications in Short-Bowel Syndrome. Journal of Parenteral and Enteral Nutrition, v. 44, n. 7, p. 9-pg., 2020-02-12. (16/18574-1, 18/14060-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ARAUJO, Iana Mizumukai de. Evaluation of bone architecture, bone marrow adipose tissue and intramuscular lipids in type 2 diabetes mellitus. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.