| Grant number: | 17/09688-6 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | October 01, 2017 |
| End date: | January 31, 2018 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Antonio Carlos Cicogna |
| Grantee: | Danielle Fernandes Vileigas |
| Supervisor: | Robert Jeffrey Beynon |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| Institution abroad: | University of Liverpool, England |
| Associated to the scholarship: | 14/22152-0 - Myocardial proteome of obese rats by Western diet with cardiac dysfunction, BP.DR |
Abstract The obesity has been identified as a nutritional disorder related to high incidence of comorbidities, including cardiovascular diseases. Abundant evidence shows that excess of adipose tissue is associated with deleterious effect in the heart function in both humans and animal models, however the mechanisms related to damage cardiovascular are not fully elucidated, thus studies in this direction are a trend in health field. The high technological advancement of equipment and methods of analysis is leading to a more precise understanding of the mechanisms responsible for pathophysiological processes. In this context, one of the research approaches that have been highlighted in the last decade is the proteomics. In order to achieve faster, cleaner and simpler protein quantification results, there has been increased interest in label-free shotgun proteomics analysis. Cardiovascular proteomics is one of the most studied areas in the field of proteomic health; however, in models of obesity by diet, it has been little explored, not being found studies that used label-free proteomic methods. Therefore, this study aims to identify the myocardial proteins that are differently expressed between obese with cardiac dysfunction and healthy rats using label-free shotgun proteomic approach. The results will reveal changes in the heart proteome associated with Western diet-induced obesity, providing insights to better understand the mechanisms involved in heart disease, as well as potential therapeutic targets for the preventing and/or treatments of cardiac complications in obese patient. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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