Total Synthesis of Eremantholide A and C

• Grant number: 17/08128-7
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: December 01, 2017
• End date: November 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ronaldo Aloise Pilli
• Grantee: Karla Santos Feu
• Supervisor: Phil Baran
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Scripps Research Institute, San Diego, United States
• Associated to the scholarship: 15/24765-1 - TOTAL SYNTHESIS OF CRYPTOPYRANMOSCATONES B2 AND B4, BP.PD

Abstract

In connection with our interests in the total synthesis of brazilian natural products, this project aims the total synthesis of (+)-Eremantholide A and the first total synthesis of (-)-Eremantholide C. Our novel asymmetric route to both complex natural products is based on a biomimetic approach, starting from a germacrane-type sesquiterpene already reported, which is derived from commercial farnesol. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SHANG, MING; FEU, KARLA S.; VANTOUROUT, JULIEN C.; BARTON, LISA M.; OSSWALD, HEATHER L.; KATO, NOBUTAKA; GAGARING, KERSTIN; MCNAMARA, CASE W.; CHEN, GANG; HU, LIANG; et al. Modular, stereocontrolled C-beta-H/C-alpha-C activation of alkyl carboxylic acids. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 116, n. 18, p. 8721-8727, APR 30 2019. (17/08128-7)

WANG, JIE; SHANG, MING; LUNDBERG, HELENA; FEU, KARLA S.; HECKER, SCOTT J.; QIN, TIAN; BLACKMOND, DONNA G.; BARAN, PHIL S.. Cu-Catalyzed Decarboxylative Borylation. ACS CATALYSIS, v. 8, n. 10, p. 9537-9542, OCT 2018. (17/08128-7)