| Grant number: | 17/03202-4 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | June 01, 2017 |
| End date: | May 31, 2019 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Physical-Chemistry |
| Agreement: | Coordination of Improvement of Higher Education Personnel (CAPES) |
| Principal Investigator: | Maria Isabel Felisberti |
| Grantee: | Cony Gauche |
| Host Institution: | Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| Associated research grant: | 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM |
Abstract The aim of this project is to develop hydrogels from poly(2-oxazoline) and cellulose nanocrystals. Nowadays, hydrogels and nanogels have been studied as its use in the manufacture of contact lenses, hygienic products, tissue engineering, drug delivery systems and wound care, for example. Besides that, great efforts have been made in the development of hydrogels responsiveness to pH, temperature, ionic strength, UV radiation, among others. Hydrogels' mechanical properties can be a challenge to their suitability in biomedical applications. In this context, this work suggest a new synthetic way for a biomaterial composed by cellulose nanocrystals functionalized by poly(2-oxazoline) chains allying reinforcement properties from the nanorods with versatile properties of this polymer, such as thermo-responsiveness and the reactivity allowing its functionalization. Experimentally, cellulose nanocrystals' surface will be oxidized (mediated by TEMPO-oxidation), which will allow the grafting of partially hydrolyzed poly(2-oxazoline) chains by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) / 4-dimethylaminopyridine (DMAP) in an amination reaction. Partial hydrolysis of poly(2-oxazoline) lateral chains will be performed allowing hydrogel formation by the polymer chains crosslinking using two different cross-linkers (acrylate and NHS-ester functions), in different experimental conditions (such as, polymer concentration, polymerization degree, hydrolysis percentage, temperature and other parameters). The final mechanical, rheological and structural properties of the hydrogels will be investigated by using DSC, TGA, SEM, rheological tests and texture measurements. (AU) | |
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