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Influence of galectin-3 on course of infection by Cryptococcus neoformans

Grant number: 16/25167-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2017
Effective date (End): May 31, 2019
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Fausto Bruno dos Reis Almeida
Grantee:Caroline Patini de Rezende
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:16/03322-7 - Role of galectin-3 in the Cryptococcus neoformans infection, AP.JP


Cryptococcus neoformans is the causative agent of cryptococcosis and a major pathogen for immunosuppresed individuals. C. neoformans represents a unique model in cell biology studies since it is the only eukaryotic pathogen with a polysaccharide capsule. Futhermore, produces extracellular vesicles containing it major virulence factor. These vesicles cross the cell wall to reach the extracellular space, where the polysaccharide is supposedly used for capsule growth or delivered into host tissues. Galectin-3, a glycan-binding protein, control a broad spectrum of immunological functions, including cell adhesion, migration, activation, apoptosis and cytokine secretion within innate and adaptive immune compartments. Under the supervision of Dr. Arturo Casadevall in the Albert Einstein College of Medicine in New York, our group have verified that galectin-3 has lytic effect on extracellular vesicles of C. neoformans and we also have detected high serum levels of galectin-3 in the course of cryptococcosis murine experimental. These observations motivate the proposal to study the role of galectin-3 in the course of infection by C. neoformans. More specifically, we propose to do the following aims: (1) to compare the survival of C. neoformans infection between wild and knockout mice (galectin-3 KO), (2) to investigate the role of galectin-3 in the course of C. neoformans infection in mice through histhological and immunological parameters, (3) to analyze comparatively the gene profile of the host innate immune response during cryptococcosis, by real-time PCR arrangement (PCR Array), the modulation of genes related to response antifungal, as well as in addition to compare with the genic modulation of galectin-3 KO mice infected by C. neoformans. Our expectation is that galectin-3 may be responsible for important roles on the infection process by C. neoformans infection. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REZENDE, CAROLINE PATINI; BRITO, PATRICIA KELLEN MARTINS OLIVEIRA; DA SILVA, THIAGO APARECIDO; PESSONI, ANDRE MOREIRA; RAMALHO, LEANDRA NAIRA ZAMBELLI; ALMEIDA, FAUSTO. Influence of Galectin-3 on the Innate Immune Response during Experimental Cryptococcosis. JOURNAL OF FUNGI, v. 7, n. 6, . (16/03322-7, 16/25167-3)
MARTINS OLIVEIRA-BRITO, PATRICIA KELLEN; REZENDE, CAROLINE PATINI; ALMEIDA, FAUSTO; ROQUE-BARREIRA, MARIA CRISTINA; DA SILVA, THIAGO APARECIDO. iNOS/Arginase-1 expression in the pulmonary tissue over time during Cryptococcus gattii infection. Innate Immunity, v. 26, n. 2, . (16/03322-7, 16/23112-7, 16/04877-2, 16/10446-4, 16/25167-3)
REZENDE, CAROLINE PATINI; MARTINS OLIVEIRA BRITO, PATRICIA KELLEN; PESSONI, ANDRE MOREIRA; DA SILVA, THIAGO APARECIDO; GOLDMAN, GUSTAVO H.; ALMEIDA, FAUSTO. Altered expression of genes related to innate antifungal immunity in the absence of galectin-3. VIRULENCE, v. 12, n. 1, p. 981-988, . (16/03322-7, 16/25167-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
REZENDE, Caroline Patini de. Influence of galectina-3 on the course of infection by Cryptococcus neoformans. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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